(E)-Caffeic acid phenethyl ester
(E)-Caffeic acid phenethyl ester is an inhibitor of iNOS and NF-κB. (E)-Caffeic acid phenethyl ester blocks the activation of iNOS by inhibiting NF-κB, and suppresses iNOS promoter activity at the NF-κB site. (E)-Caffeic acid phenethyl ester inhibits nitric oxide production in activated macrophages. (E)-Caffeic acid phenethyl ester is applicable to anti-inflammatory research.
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- CAS. Nr.: 115610-29-2
- Formel: C17H16O4
- Molecular Weight:284.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
(E)-Caffeic acid phenethyl ester (Compound 10) (2-200 μM; 24 h) potently inhibits NO production in LPS (HY-D1056)-activated mouse macrophage-like J774.1 cells, with an IC50 of 5.44 μM, and shows no cytotoxicity at concentrations close to its IC50[1].
(E)-Caffeic acid phenethyl ester (1-100 μM; 24 h) potently inhibits NO production in LPS-activated mouse macrophage-like J774.1 cells, with an IC50 of 7.64 μM[1].
(E)-Caffeic acid phenethyl ester (1-100 μM; 24 h) shows no cytotoxicity toward LPS-treated mouse macrophage-like J774.1 cells at concentrations close to its NO inhibitory IC50 (7.64 μM), but exhibits cytotoxicity at concentrations of 50 μM and 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:murine macrophage-like J774.1 cells
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Concentration:1, 10, 20, 50, 100 μM
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Incubation Time:24 h
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Result:Showed cell viabilities of 99.4%, 115%, 110%, 82.3%, and 67.4% respectively relative to the LPS-treated control at 1, 10, 20, 50, and 100 μM.
Exhibited cytotoxicity (cell viability < 90%) at 50 μM and 100 μM, but not at concentrations around the IC50 value of 7.64 μM.
Chemical Information
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CAS. Nr. 115610-29-2
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Molecular Weight 284.31
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Formel C17H16O4
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SMILES
C(=C/C(OCCC1=CC=CC=C1)=O)\C2=CC(O)=C(O)C=C2
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Structure Classification
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Initial Source
Propolis
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(E)-Caffeic acid phenethyl ester Related Classifications
HY-W1058007 Related Classifications
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