F2276-0008
F2276-0008 is a potential PCAF bromodomain (PDB 5FDZ) inhibitor. F2276-0008 is predicted to have good cell permeability and oral absorption. F2276-0008 exhibits a stable C-alpha backbone RMSD and maintains compactness. F2276-0008 can be used for cancer-related research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 922000-45-1
- Formel: C22H20N2O4
- Molecular Weight:376.41
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
F2276-0008 exhibits a highly favorable binding free energy (ΔGBind) of -93.853 kcal/mol with PCAF BRD[1].
F2276-0008 is predicted to have good drug-like properties, with 100% human oral absorption and good cell permeability[1].
F2276-0008 has HOMO, LUMO, and HLG values of -0.207, -0.049, and -0.158, respectively, indicating its chemical reactivity[1].
F2276-0008 forms a stable complex with PCAF BRD, with an RMSD of 1.2 Å[1].
F2276-0008 interacts with the PCAF BRD complex mainly through Asn803, Tyr809, and Tyr802[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 922000-45-1
-
Molecular Weight 376.41
-
Formel C22H20N2O4
-
SMILES
O=C(NC1=CC=C2OCCN(C(=O)C2=C1)C)COC=3C=CC=4C=CC=CC4C3
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
F2276-0008 Related Classifications
HY-153147 Related Classifications
Powered by Bioz