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Art. -Nr.: HY-P10997

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F3 peptide

F3 peptide is a nucleolin-binding tumor-homing peptide that mediates selective uptake and internalization by tumor cells. F3 peptide is a 31-amino acid fragment of human high mobility group nucleosomal protein 2 (HMGN2). F3 peptide inhibits protein synthesis through ribosome inactivation. F3 peptide targets the tumor vasculature. F3 peptide can serve as an effective ligand to improve the druggability of macromolecular drugs or nanoparticles. F3 peptide is used in research on cancers such as glioblastoma and breast cancer.

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CAS. Nr.: 536971-53-6
Formel: C₁₅₂H₂₆₃N₄₉O₄₁
Molecular Weight:3433.02

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

F3 peptide Chemical Structure

CAS. Nr.: 536971-53-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

FITC-F3 peptide (10 nM; 2 h) binds to the 231-H2N cell membrane, internalizes, and translocates to the nucleus and nucleolus, colocalizing with nucleolin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Immunofluorescence^[2]

View Protocol

Cell Line:

MDA-MB-231-H2N (231-H2N) human breast cancer cells
Concentration:

10 nM
Incubation Time:

2 h
Result:

Showed membrane-bound and internalized fluorescence.
Observed in the nuclei, where it co-localized with nucleolin in the nucleoli.
Nuclear localization was approximately 33.6% of the total amount internalized.

Chemical Information

CAS. Nr. 536971-53-6
Molecular Weight 3433.02
Formel C₁₅₂H₂₆₃N₄₉O₄₁
Sequence

Lys-Asp-Glu-Pro-Gln-Arg-Arg-Ser-Ala-Arg-Leu-Ser-Ala-Lys-Pro-Ala-Pro-Pro-Lys-Pro-Glu-Pro-Lys-Pro-Lys-Lys-Ala-Pro-Ala-Lys-Lys
Sequence Shortening

KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Animals and Diseases

Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ham SH, et al. Molecular tumor targeting of gelonin by fusion with F3 peptide. Acta pharmacologica Sinica. 2017 Jun;38(6):897-906. [Content Brief]

[2]. Cornelissen B, et al. 111In-BnDTPA-F3: an Auger electron-emitting radiotherapeutic agent that targets nucleolin. EJNMMI research. 2012 Feb 20;2:9.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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