VAMP2 - vesicle associated membrane protein 2 Gene

Also Known as SYB2; VAMP-2; NEDHAHM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6844

About VAMP2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,159,147-8,162,948 (from NCBI)

This gene has 4 transcripts (splice variants), 153 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 159.3), ovary (RPKM 45.0) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

VAMP2 Products (2)

mRNA	Protein	Name
NM_001330125.1	NP_001317054.1	vesicle-associated membrane protein 2 isoform 2
NM_014232.3	NP_055047.2	vesicle-associated membrane protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9920726	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	12855681	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in eosinophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
NOT involved in mucus secretion	IMP IMP: Inferred from mutant phenotype	22144578	GOA
NOT involved in natural killer cell degranulation	IMP IMP: Inferred from mutant phenotype	18042464	GOA
NOT involved in neutrophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
NOT involved in regulation of histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	18253931	GOA
involved in vesicle fusion	IMP IMP: Inferred from mutant phenotype	30929742	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	12130530	GOA
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	19478182	GOA
located in membrane	IDA IDA: Inferred from direct assay	16677249	GOA
NOT located in secretory granule membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in vesicle	IDA IDA: Inferred from direct assay	17313651	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAMP2 Protein Structure

Synaptobrevin

0
100
116 a.a.

Protein Preferred Names	Protein Names
vesicle-associated membrane protein 2	synaptobrevin 2

VAMP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	VAMP2	P63027	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	VAMP2	P63027	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	VAMP2	P63027	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	VAMP2	P63027	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	VAMP2	P63027	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	VMA21	Homo sapiens	Q3ZAQ7	Validated Y2H	32296183
Intra	VAMP2	P63027	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
Intra	VAMP2	P63027	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	VAMP2	P63027	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	VAMP2	P63027	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	VAMP2	P63027	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	VAMP2	P63027	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	PRKD3	Homo sapiens	O94806	Pull Down	17196367
Intra	VAMP2	P63027	PRKD3	Homo sapiens	O94806	Anti Tag CoIP	17196367
Intra	VAMP2	P63027	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	VAMP2	P63027	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	VAMP2	P63027	MARCHF8	Homo sapiens	Q5T0T0	Validated Y2H	32296183
Intra	VAMP2	P63027	MARCHF8	Homo sapiens	Q5T0T0	Y2H Array	32296183
Intra	VAMP2	P63027	MARCHF8	Homo sapiens	Q5T0T0	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	VAMP2	P63027	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	VAMP2	P63027	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	VAMP2	P63027	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	VAMP2	P63027	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	VAMP2	P63027	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	VAMP2	P63027	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	VAMP2	P63027	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	VAMP2	P63027	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	VAMP2	P63027	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	VAMP2	P63027	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	VAMP2	P63027	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	VAMP2	P63027	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	VAMP2	P63027	TMEM101	Homo sapiens	Q96IK0	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	TMEM101	Homo sapiens	Q96IK0	Validated Y2H	32296183
Intra	VAMP2	P63027	TMEM101	Homo sapiens	Q96IK0	Y2H Array	32296183
Intra	VAMP2	P63027	SNAP29	Homo sapiens	O95721	Y2H Prey Pooling	25416956
Intra	VAMP2	P63027	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	VAMP2	P63027	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	VAMP2	P63027	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	VAMP2	P63027	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	VAMP2	P63027	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	VAMP2	P63027	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	VAMP2	P63027	STX1A	Homo sapiens	Q16623	Anti Bait CoIP	20798282
Intra	VAMP2	P63027	STX4	Homo sapiens	Q12846	Validated Y2H	32296183
Intra	VAMP2	P63027	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	VAMP2	P63027	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	VAMP2	P63027	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	VAMP2	P63027	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	VAMP2	P63027	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	VAMP2	P63027	STX1B	Homo sapiens	P61266	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	STX1B	Homo sapiens	P61266	Y2H Array	32296183
Intra	VAMP2	P63027	SNCA	Homo sapiens	P37840	Anti Bait CoIP	20798282
Intra	VAMP2	P63027	SNCA	Homo sapiens	P37840	Pull Down	20798282
Intra	VAMP2	P63027	SNCA	Homo sapiens	P37840	Density Sedimentation	20798282
Cross	VAMP2	P63027	F	Clostridium botulinum	A7GBG3	Protease Assay	22172278

Cross: Cross-species interaction Intra: Intraspecies interaction

VAMP2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81673	VAMP2 Antibody (YA1418)	WB, IP	Human, Mouse, Rat
HY-P81673A	VAMP2 Antibody (YA1418)(PBS only)	WB, IP	Human, Mouse, Rat
HY-P84433	VAMP2 Antibody (YA4130)	IHC-P, FC, ELISA	Human, Mouse, Monkey, Rat
HY-P84433A	VAMP2 Antibody (YA4130)(PBS only)	IHC-P, FC, ELISA	Human, Mouse, Monkey, Rat

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Hypotonia And Autistic Features With Or Without Hyperkinetic Movements	NEDHAHM Neurodevelopmental Disorder, Hypotonia And Autistic Features With/Without Hyperkinetic Movements
Tetanus	Lockjaw Clostridial Tetanus Infection Due To Clostridium Tetani Lock-Jaw
Foodborne Botulism	Botulism Botulism Poisoning Intoxication With Clostridium Botulinum Toxin Wound Botulism Food Poisoning Due To Clostridium Botulinum Infection Due To Clostridium Botulinum Infant Botulism Intoxication Botulism Botulism, Infantile Clostridium Botulinum Poisoning Botulism Nos
Infant Botulism	Infant Intestinal Botulism Infant Intestinal Toxemia Botulism Infant Intestinal Toxin-Mediated Botulism Infantile Botulism Botulism, Infantile
Partial Optic Atrophy
Wound Botulism	Cutaneous Infectious Botulism Cutaneous Toxin-Mediated Botulism Inoculation Botulism Skin Infectious Botulism Skin Toxin-Mediated Botulism
Gastrointestinal Tularemia	Enteric Tularemia Intestinal Tularaemia
Primary Bacterial Infectious Disease
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P10809	VAMP	Inhibitor	98.13%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P5366	PEP1	Modulator	99.88%	Unkown
HY-RS15594	VAMP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21080	Vamp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27597	Vamp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VAMP2	MGD	MGI:1313277
Rattus norvegicus	VAMP2	RGD	RGD:3949
Others	VAMP2	NCBI