country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-187337

Copy Link Print Information

HaloPROTAC 4

HaloPROTAC 4 is a HaloPROTAC degrader with a pIC₅₀ of 8.1 against human CRBN. HaloPROTAC 4 binds to CRBN to recruit the CUL4^CRBN E3 ubiquitin ligase complex, and covalently binds to HaloTag fusion proteins, thereby inducing proteasome-dependent degradation of HaloTag fusion proteins. HaloPROTAC 4 serves as a protein knockdown tool for chemogenetic-related studies.
(Pink: Cereblon ligand (HY-187338); Blue: E3 ligase ligand; Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₄₃H₆₀ClN₅O₇
Molecular Weight:794.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

HaloPROTAC 4 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

HaloPROTAC 4 is a HaloPROTAC degrader with a pIC₅₀ of 8.1 against human CRBN. HaloPROTAC 4 binds to CRBN to recruit the CUL4^CRBN E3 ubiquitin ligase complex, and covalently binds to HaloTag fusion proteins, thereby inducing proteasome-dependent degradation of HaloTag fusion proteins. HaloPROTAC 4 serves as a protein knockdown tool for chemogenetic-related studies^[1]. (Pink: Cereblon ligand (HY-187338); Blue: E3 ligase ligand; Black: linker).

IC₅₀ & Target^[1]

Cereblon

8.1 (pIC₅₀)

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

HaloPROTAC 4 (compound 15) binds to purified cereblon protein, with a mean pIC₅₀ of 8.1^[1].
HaloPROTAC 4 induces dose-dependent degradation of FAK-HaloTag-HiBiT in A549 cells, with a pDC₅₀ of 8.57 and a D_max of 59.5% after 24 h of incubation; in addition, the degradation of FAK-HaloTag-HiBiT depends on CRBN binding, HaloTag binding, cullin neddylation and proteasome activity^[1].
HaloPROTAC 4 induces dose-dependent degradation of endogenous MARC1-HaloTag-HiBiT and HiBiT-HaloTag-BRD4 in HEK293 cells, with a maximum degradation rate of approximately 80% after 24 h of incubation; in addition, the degradation of HiBiT-HaloTag-BRD4 shows concentration dependence^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 794.42
Formel C₄₃H₆₀ClN₅O₇
SMILES

O=C1NC(CCN1C2=CC=CC3=C2C=CN3C4CCN(CCC5CCN(C(C6=CC=C(OCCOCCOCCOCCCCCCCl)C=C6)=O)CC5)CC4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Stevens R, et al. A Systematic Direct-to-Biology Approach Identified Potent Cereblon HaloPROTACs. ACS chemical biology. 2026 Jul 17;21(7):1798-1817. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

HaloPROTAC 4

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HaloPROTAC 4 Related Classifications

HY-187337 Related Classifications