Heveadride
Heveadride is a fungal metabolite and an antifungal agent. Heveadride is active against various filamentous fungi and some human pathogenic yeasts. Heaveadride induces down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells with an IC50 of 82.7 μM.
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- CAS. Nr.: 39595-41-0
- Formel: C18H20O6
- Molecular Weight:332.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
Heveadride (Compound 2) (5 and 10 μg/disc) shows moderate inhibitory activity against filamentous fungi, and has no activity against yeast at a concentration of 5 μg/disc, while has weak activity against some yeast species at a concentration of 100 μg/disc[1].
Heveadride (Compound 4) (10-100 μM, 2 h) demonstrates dose-dependent inhibitory activity against TNFα-induced NF-κB in K562 cells[2].
Heveadride (0.1-100 μM, 8-72 h) does not significantly decrease K562 cell viability at any concentration or measured time point but reduces K562 proliferation at 100 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 39595-41-0
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Molecular Weight 332.35
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Formel C18H20O6
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SMILES
CCC[C@@H]1C2=C(C(OC2=O)=O)CCC3=C(C(OC3=O)=O)C[C@H]1CC
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Structure Classification
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Initial Source
Helmin thosporium heveae
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Hosoe T, et al. A new nonadride derivative, dihydroepiheveadride, as characteristic antifungal agent against filamentous fungi, isolated from unidentified fungus IFM 52672. J Antibiot (Tokyo). 2004 Sep;57(9):573-8. [Content Brief]
[2]. Harms H, et al. Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces cejpii with NF-κB Inhibitory Potential. Mar Drugs. 2015 Aug 6;13(8):4949-66. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Heveadride Related Classifications
HY-N15653 Related Classifications
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