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Art. -Nr.: HY-180392

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IAG-10

IAG-10 is a selective DNA polymerase kappa (hpol κ) inhibitor with an IC₅₀ value of 7.2 μM. IAG-10 exerts its function by disrupting the formation of the binary complex between the enzyme and DNA. IAG-10 enhances the antiproliferative and DNA-damaging activities of Temozolomide (HY-17364) in tumor cells with functional hpol κ expression. IAG-10 can be used in the research of cancers such as malignant brain tumors.

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CAS. Nr.: 2361305-69-1
Formel: C₂₁H₁₇Cl₂N₅O
Molecular Weight:426.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

IAG-10 Chemical Structure

CAS. Nr.: 2361305-69-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

DNA Polymerase

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

IAG-10 (0.1-0.5 μM; 1 hour) potentiates the anti-proliferative effect of Temozolomide (HY-17364) in hpol κ-proficient HAP-1 cells but not in hpol κ-deficient cells, indicating target-dependent activity^[1].
IAG-10 (0.5 μM; 1 hour) increases DNA damage in hpol κ-proficient HAP-1 cells alone and in combination with Temozolomide (HY-17364), with no effect in hpol κ-deficient cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

hpol κ-proficient (HAP-1), hpol κ-deficient (HAP-1 hpol κ KO) cells
Concentration:

0.1 μM, 0.5 μM
Incubation Time:

1 hour
Result:

Reduced colony formation by hpol κ-proficient cells at all TMZ concentrations tested when co-treated with 0.5 μM IAG-10 compared to TMZ alone.
Reduced colony formation to ~40% of untreated cells at 250 μM TMZ + 0.5 μM IAG-10, while TMZ alone allowed ~75% colony formation.
Caused no significant reduction in hpol κ-deficient cells.

Chemical Information

CAS. Nr. 2361305-69-1
Molecular Weight 426.30
Formel C₂₁H₁₇Cl₂N₅O
SMILES

O=C(N1C=C(C2=C1C=CC(Cl)=C2)/C=N/NC(N)=N)C3=CC=CC4=C3C=CC=C4.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ketkar A, et al. Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms. ACS Chem Biol. 2019;14(6):1337-1351. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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IAG-10

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

IAG-10 Related Classifications

HY-180392 Related Classifications