country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-136734

Copy Link Print Information

JAK2-IN-5

JAK2-IN-5 (Compound 13) is a selective JAK kinase inhibitor, with an IC₅₀ of 0.078 μM against JAK-2 and an IC₅₀ of 0.206 μM against JAK-2^V617F. JAK2-IN-5 can be used for the research of myeloproliferative disorders.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1110502-30-1
Formel: C₁₇H₂₀N₄O₂S
Molecular Weight:344.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

JAK2-IN-5 Chemical Structure

CAS. Nr.: 1110502-30-1

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-13034

Gandotinib

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

JAK2

0.078 μM (IC₅₀)

JAK2^V617F

0.206 μM (IC₅₀)

Alle JAK Isoform-spezifische Produkte anzeigen :

In Vitro

JAK2-IN-5 potently inhibits JAK-2 WT kinase with an IC₅₀ of 78 nM and a ligand efficiency of 0.41 kcal mol^-1^[1].
JAK2-IN-5 inhibits JAK-2^V617F mutant kinase with an IC₅₀ of 206 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1110502-30-1
Molecular Weight 344.43
Formel C₁₇H₂₀N₄O₂S
SMILES

O=S(=O)(NC(C)(C)C)C=1C=CC(=CC1)C2=CC=C3NN=C(N)C3=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Antonysamy S, et al. Fragment-based discovery of JAK-2 inhibitors. Bioorg Med Chem Lett. 2009;19(1):279-282. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

JAK2-IN-5

Gandotinib

Alle JAK Isoform-spezifische Produkte anzeigen