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Art. -Nr.: HY-189472

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KB02

Name: KB02
Brand: MedChemExpress
SKU: HY-189472
Price: 490.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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KB02 is a DCAF16-recruiting ligand that covalently binds to a ligandable cysteine on DCAF16, recruiting the E3 ligase to mediate target protein degradation. KB02 serves as a DCAF16-binding fragment for the synthesis of SHP2 PROTACs.

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Reinheit : 99.89%
CAS. Nr.: 62265-73-0
Formel: C₁₁H₁₂ClNO₂
Molecular Weight:225.67

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

KB02 Chemical Structure

CAS. Nr.: 62265-73-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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Beschreibung

IC₅₀ & Target

DCAF16

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen :

In Vitro

KB02 (7.5 μM; 24 h) alone does not induce SHP2 degradation in HeLa cells but competes with SK8 for DCAF16 binding, thereby inhibiting SK8-induced SHP2 degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HeLa
Concentration:

7.5 μM
Incubation Time:

24 h
Result:

Lacked the capability to induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.\nDid not induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.

Chemical Information

CAS. Nr. 62265-73-0
Appearance Solid
Molecular Weight 225.67
Formel C₁₁H₁₂ClNO₂
Color White to off-white
SMILES

OC1=CC=C(N(C(CCl)=O)CCC2)C2=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pang X, et al. Discovery of DCAF16-based PROTACs as SHP2 degraders. Bioorganic chemistry. 2026 Oct 05;181:110372.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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KB02

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen

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