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Art. -Nr.: HY-189472

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KB02

KB02 is a DCAF16-recruiting ligand that covalently binds to a ligandable cysteine on DCAF16, recruiting the E3 ligase to mediate target protein degradation. KB02 serves as a DCAF16-binding fragment for the synthesis of SHP2 PROTACs.

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CAS. Nr.: 62265-73-0
Formel: C₁₁H₁₂ClNO₂
Molecular Weight:225.67

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

KB02 Chemical Structure

CAS. Nr.: 62265-73-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Calculators
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Classifications
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Beschreibung

IC₅₀ & Target

DCAF16

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen :

In Vitro

KB02 (7.5 μM; 24 h) alone does not induce SHP2 degradation in HeLa cells but competes with SK8 for DCAF16 binding, thereby inhibiting SK8-induced SHP2 degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HeLa
Concentration:

7.5 μM
Incubation Time:

24 h
Result:

Lacked the capability to induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.\nDid not induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.

Chemical Information

CAS. Nr. 62265-73-0
Molecular Weight 225.67
Formel C₁₁H₁₂ClNO₂
SMILES

OC1=CC=C(N(C(CCl)=O)CCC2)C2=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Pang X, et al. Discovery of DCAF16-based PROTACs as SHP2 degraders. Bioorganic chemistry. 2026 Oct 05;181:110372.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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KB02

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen

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IC50 & Target

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Chemical Information

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KB02 Related Classifications

HY-189472 Related Classifications

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