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Art. -Nr.: HY-116597

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L-783483

(Synonyms: F3MethylAA)

L-783483 (F3MethylAA) is an agonist for PPARδ. L-783483 ameliorates Carrageenan (HY-125474)-induced paw edema in mice.

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CAS. Nr.: 194608-77-0
Formel: C₂₂H₂₁ClF₃NO₄S
Molecular Weight:487.92

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

L-783483 Chemical Structure

CAS. Nr.: 194608-77-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

L-783483 (F3MethylAA) is an agonist for PPARδ. L-783483 ameliorates Carrageenan (HY-125474)-induced paw edema in mice^[1].

IC₅₀ & Target

PPARδ

Alle PPAR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	5900 nM Compound: 1	Activity at LXR alpha as beta-lactamase transactivation in CHO cells Activity at LXR alpha as beta-lactamase transactivation in CHO cells	[PMID: 16529931]
CHO	EC₅₀	7300 nM Compound: 1	Activity at LXR beta as beta-lactamase transactivation in CHO cells Activity at LXR beta as beta-lactamase transactivation in CHO cells	[PMID: 16529931]
HEK293	EC₅₀	1080 nM Compound: 1	Effective concentration against liver X receptor-beta in HEK293 cell transactivation assay Effective concentration against liver X receptor-beta in HEK293 cell transactivation assay	[PMID: 15911262]
HEK293	EC₅₀	1790 nM Compound: 1	Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assay Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assay	[PMID: 15911262]

Chemical Information

CAS. Nr. 194608-77-0
Molecular Weight 487.92
Formel C₂₂H₂₁ClF₃NO₄S
SMILES

O=C(CC1=CC=C(C(Cl)=C1)SCCCOC2=C(CCC)C(ON=C3C(F)(F)F)=C3C=C2)O
Synonyms

F3MethylAA
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wan YJ, et al., Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X ReceptorAlpha. PPAR Res. 2006;2006:96341. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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