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Art. -Nr.: HY-P99301

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Biologically Validated

Lokivetmab

Name: Lokivetmab
Brand: MedChemExpress
SKU: HY-P99301
Price: 300.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Anti-Canine IL31 Recombinant Antibody; CAN34D3-65; PF-06443537)

Kundenbewertung

Based on 1 Customer Validation

Lokivetmab (Anti-Canine IL31 Recombinant Antibody) is an anti-canine IL-31 monoclonal antibody. Lokivetmab inhibits IL-31-mediated activation of pruritogenic signals in peripheral sensory neurons and reduces TH2-weighted inflammation. Lokivetmab demonstrates long-term efficacy in controlling pruritus and improving skin lesions in dogs with canine atopic dermatitis (CAD). Lokivetmab can be used for the research of atopic dermatitis (AD) in dogs.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.34%
CAS. Nr.: 1533403-95-0
Molecular Weight:147.51 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lokivetmab Chemical Structure

CAS. Nr.: 1533403-95-0

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Canine IgG2 kappa

Recommend Isotype Controls

Canine IgG2 kappa, Isotype Control

Species Reactivity

Canine

IC₅₀ & Target

^[1]

IL-31

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vivo

Lokivetmab (2 mg/kg, i.v. injection, every 4-8 weeks, 12 months) shows long-term efficacy in controlling pruritus and improving skin lesions in dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Canine atopic dermatitis (CAD) dog model^[1]
Dosage:

2 mg/kg
Administration:

i.v. injection, every 4-8 weeks, 12 months
Result:

Achieved pruritus control with 87% (64/75) of dogs maintaining PVAS below baseline.
Improved skin lesions with mean VetVAS (skin lesion score).

Related Protocols :

Gene ID

256353430 [NCBI]

Accession

BAH97742

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG2-kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-31 Protein, Canine (HEK293, His, HY-P703718) can bind Lokivetmab. The EC₅₀ for this effect is 59.37 ng/mL.

Chemical Information

CAS. Nr. 1533403-95-0
Appearance Liquid
Molecular Weight 147.51 kDa
Color Colorless to light yellow
SMILES

[Lokivetmab]
Synonyms

Anti-Canine IL31 Recombinant Antibody; CAN34D3-65; PF-06443537
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (256 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Gober M, et al. Long term use of lokivetmab (Cytopoint®) in atopic dogs. BMC Vet Res. 2025 Mar 26;21(1):203. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Lokivetmab

HOLO Human Interleukin-2 (IL-2) Detection Kit

Protein A Agarose

Cell-ATP Viability Detection Kit

Bradford Protein Assay Kit

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

Alle Interleukin Related Isoform-spezifische Produkte anzeigen