Meropenem-vaborbactam
Based on 1 Customer Validation
Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC50 of 0.5 μg/mL and an MIC90 of 8 μg/mL.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 97.91%
- CAS. Nr.: 2031124-72-6
- Formel: C29H41BN4O10S2
- Molecular Weight:680.60
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Biologische Aktivität
Meropenem-vaborbactam (≤1-≤2 μg/mL) potently inhibits Enterobacteriaceae isolates, with an MIC50 of ≤0.015 μg/mL and an MIC90 of 0.06 μg/mL; 99.1% and 99.3% of the isolates are inhibited at concentrations of ≤1 μg/mL and ≤2 μg/mL, respectively[1].
Meropenem-vaborbactam exhibits activity against isolates of Pseudomonas aeruginosa, with an MIC50 of 0.5 μg/mL and an MIC90 of 8 μg/mL[1].
Meropenem-vaborbactam exhibits potent in vitro activity against 991 KPC-producing Enterobacterales strains, with an MIC50 of 0.06 mg/L and an MIC90 of 1 mg/L[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:neutropenic mice[2]
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Dosage:meropenem 2 g; vaborbactam 8 mg/L (as combination)
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Administration:3-hour infusion; every 8 hours
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Result:Achieved bacteriostasis at an fAUC:MIC ratio of 9.
Achieved a 1-log10 kill against KPC-producing Enterobacteriaceae at an fAUC:MIC ratio of 38.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 2031124-72-6
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Appearance Solid
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Molecular Weight 680.60
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Formel C29H41BN4O10S2
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Color Light yellow to yellow
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SMILES
OC(C1=C(S[C@H]2C[C@H](NC2)C(N(C)C)=O)[C@H](C)[C@@]([C@@]3([H])[C@H](O)C)([H])N1C3=O)=O.O=C(CC4=CC=CS4)N[C@@H]5B(O[C@@H](CC5)CC(O)=O)O
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Synonyms
Carbavance
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 10 mg/mL (14.69 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Castanheira M, et al. Meropenem-Vaborbactam Tested against Contemporary Gram-Negative Isolates Collected Worldwide during 2014, Including Carbapenem-Resistant, KPC-Producing, Multidrug-Resistant, and Extensively Drug-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2017;61(9):e00567-17. Published 2017 Aug 24. [Content Brief]
[2]. Petty LA, et al. Overview of meropenem-vaborbactam and newer antimicrobial agents for the treatment of carbapenem-resistant Enterobacteriaceae. Infect Drug Resist. 2018 Sep 12;11:1461-1472. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.4693 mL | 7.3465 mL | 14.6929 mL | 36.7323 mL |
| 5 mM | 0.2939 mL | 1.4693 mL | 2.9386 mL | 7.3465 mL | |
| 10 mM | 0.1469 mL | 0.7346 mL | 1.4693 mL | 3.6732 mL |
Meropenem-vaborbactam Related Classifications
HY-111521 Related Classifications
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- Meropenem-vaborbactam
- 2031124-72-6
- Carbavance
- Antibiotic
- Bacterial
- Beta-lactamase
- KPC serine carbapenemase
- complicated urinary tract infection
- Ambler class A serine beta-lactamases
- penicillin-binding proteins
- Enterobacteriaceae
- Pseudomonas aeruginosa
- Stenotrophomonas maltophilia
- Ambler class C serine beta-lactamases
- Acinetobacter spp.
- gram-negative bacterial infections
- Inhibitor
- inhibitor
- inhibit