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Art. -Nr.: HY-111168

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MLS-2064

MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC₅₀: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma.

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CAS. Nr.: 906660-74-0
Formel: C₂₂H₂₄BrCl₂N₅O₂
Molecular Weight:541.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

MLS-2064 Chemical Structure

CAS. Nr.: 906660-74-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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Biologische Aktivität

Beschreibung

Alle GSK-3 Isoform-spezifische Produkte anzeigen :

In Vitro

MLS-2064 (compound 13j) (8 h) potently reduces the viability of various human tumor cell lines and embryonic kidney cell lines^[1].
MLS-2064 (48 h) induces caspase-independent cell death in SH-SY5Y cells, as its cell viability inhibitory activity is not affected by the caspase inhibitor Q-VD-OPh^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HT-29, HCT116 colon cancer, MDA-MB-231 breast cancer, A549 lung cancer, PC3 prostate cancer, 5L, BP8, F1, Huh7 hepatoma, HEK293 embryonic kidney cells
Concentration:

/
Incubation Time:

48 h
Result:

Exhibited the following IC₅₀ values for cell viability inhibition after 48 h: HT-29 (6.3 μM), HCT116 (5.4 μM), MDA-MB-231 (5.3 μM), A549 (5.9 μM), PC3 (6.1 μM), 5L (5.2 μM), BP8 (5.6 μM), F1 (1.7 μM), Huh7 (5.3 μM), HEK293 (5.0 μM).

Chemical Information

CAS. Nr. 906660-74-0
Molecular Weight 541.27
Formel C₂₂H₂₄BrCl₂N₅O₂
SMILES

O=C(/C(C1=CC=C2)=C(NC3=CC=CC=C34)/C4=N/OCCN5CCNCC5)NC1=C2Br.Cl.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ferandin Y, et al. 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. J Med Chem. 2006;49(15):4638-4649. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MLS-2064

Alle GSK-3 Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

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Help & FAQs

MLS-2064 Related Classifications

HY-111168 Related Classifications