NO-IN-1
NO-IN-1 (Compound 7a) inhibits the production of NO (IC50 = 3.13 μΜ). NO-IN-1 has anti-inflammatory effects. NO-IN-1 downregulates the expression of COX-2 and iNOS by inhibiting the NF-κB signaling pathway.
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- Formel: C33H40N4O5
- Molecular Weight:572.69
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
3.13 μM
Compound: 7a
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Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 23 hrs by Griess method
Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 23 hrs by Griess method
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[PMID: 39140047] |
Chemical Information
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Molecular Weight 572.69
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Formel C33H40N4O5
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SMILES
O=C(OCC1=CN(CCN2C(C(C3=C2C=CC=C3)=O)=O)N=N1)C/C(C=O)=C\C[C@H]4C(CC[C@@]5([H])C(C)(C)CCC[C@]45C)=C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NO-IN-1 Related Classifications
HY-163888 Related Classifications
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