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Art. -Nr.: HY-182427

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ORF 17583

ORF 17583 is a Ranitidine (HY-B0693) analogue and H2 receptor antagonist. ORF 17583 exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing. ORF 17583 can be used for research on peptic ulcers and hyperacidity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 78441-46-0
Formel: C₁₃H₂₁N₅O₂S₂
Molecular Weight:343.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ORF 17583 Chemical Structure

CAS. Nr.: 78441-46-0

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

ORF 17583 (100-1000 nM; 30 min) exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing^[1].
ORF 17583 (1-10 μM; 60 min) significantly inhibits histamine-induced gastric acid secretion at a concentration of 10 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 78441-46-0
Molecular Weight 343.47
Formel C₁₃H₂₁N₅O₂S₂
SMILES

O=S1N=C(C(NCCSCC2=CC=C(CN(C)C)O2)=N1)NC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Di Stilo A, et al. SAR studies on H2 antagonists containing alkylamino substituted 1,2, 5-thiadiazole 1-oxide moieties. Farmaco. 1998;53(8-9):536-540. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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