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OSMI-1

48 Cited Publications
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Based on 48 publication(s) in Google Scholar

OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.

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  • Reinheit: 99.88%
  • CAS. Nr.: 1681056-61-0
  • Formel: C28H25N3O6S2
  • Molecular Weight:563.64
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • OSMI-1 Chemical Structure
    OSMI-1 Chemical Structure
  • Experimental Validation Results for OSMI-1
  • Experimental Validation Results for OSMI-1
  • Experimental Validation Results for OSMI-1
  • Experimental Validation Results for OSMI-1
  • Experimental Validation Results for OSMI-1
  • Experimental Validation Results for OSMI-1
CAS. Nr.: 1681056-61-0
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  • OSMI-1 Chemical Structure
    OSMI-1 Chemical Structure
    1/16
  • 1/16

    OSMI-1 purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Jan;22(1):68-82. [Abstract]

    Customer Validation
     Representative western blot showing changes in O-GlcNAc levels in total bone marrow (BM) cells and early B (CD11b–IgM–B220+) cells from mice intraperitoneally injected with OSMI-1 (1 mg/day 10 days).

  • 1/16

    OSMI-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jan 4;15(1):252. [Abstract]

    Customer Validation
     ELISA was performed to determine IFN-β concentration in the BALF of the indicated mice (Intraperitoneally with 200 µl 1 mg/kg OSMI-1 6 h before PR8 infection, followed by once-daily administration on days 14–15).

  • 1/16

    OSMI-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jan 4;15(1):252. [Abstract]

    Customer Validation
     Relative influenza virus content in the mice (Intraperitoneally with 200 µl 1 mg/kg OSMI-1 6 h before PR8 infection, followed by once-daily administration on days 14–15) lung tissues was quantified based on M protein levels measured via RT-qPCR and shown as ΔCt fold change.

  • 1/16

    OSMI-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jan 4;15(1):252. [Abstract]

    Customer Validation
     Periodic acid-Schiff (PAS), hematoxylin and eosin (H&E), and Masson’s trichome-stained lung tissues of the indicated mice (Intraperitoneally with 200 µl 1 mg/kg OSMI-1 6 h before PR8 infection, followed by once-daily administration on days 14–15).

  • 1/16

    OSMI-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jan 4;15(1):252. [Abstract]

    Customer Validation
     Immunoblotting of P-TBK1, TBK1, P-IRF3, IRF3, and β-actin in lysates of BMDMs stimulated by 4 μg/ml Poly(I:C) for the indicated times and pretreated with 20 μg/ml OSMI-1 for 30 min.

  • 1/16

    OSMI-1 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 10;8(1):63. [Abstract]

    Customer Validation
     OSMI-1 (20 μΜ; 12 h) downregulates the O-GlcNAcylation in both HepG2-HBV1.3 cells (fig j) and Huh7-HBV1.3 cells (fig k).

  • OSMI-1