Paucimannose
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Paucimannose is a mannosidic N-glycan epitope. It acts as a carcinoembryonic antigen, and a marker for cancer, stem cell properties and inflammation. Paucimannose mainly exists in plants and invertebrates. It consists of oligomannose-type N-glycans that preferentially bind to mannose-binding lectin. Paucimannose localizes on the surface of resting cells and translocates upon cell activation. It can be used in studies related to Pseudomonas aeruginosa infection, cancer and pancreatitis.
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- CAS. Nr.: 70858-45-6
- Formel: C34H58N2O26
- Molecular Weight:910.82
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Human Endogenous Metabolite |
Paucimannose-enriched neutrophil elastase glycoforms exhibit preferential binding to mannose-binding lectin, with multivalent low-mannose structures showing the highest affinity, while sialylated glycoforms are excluded[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 70858-45-6
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Appearance Solid
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Molecular Weight 910.82
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Formel C34H58N2O26
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Color White to off-white
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SMILES
OC[C@@H](O[C@H]([C@@H]([C@H]1O)NC(C)=O)O[C@H]([C@H](O)CO)[C@H](O)[C@H](C=O)NC(C)=O)[C@H]1O[C@H]2[C@H]([C@H]([C@@H]([C@H](O2)CO[C@H]3O[C@@H]([C@H]([C@@H]([C@@H]3O)O)O)CO)O)O[C@H]4O[C@@H]([C@H]([C@@H]([C@@H]4O)O)O)CO)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Loke I, et al. Paucimannose-Rich N-glycosylation of Spatiotemporally Regulated Human Neutrophil Elastase Modulates Its Immune Functions. Mol Cell Proteomics. 2017 Aug;16(8):1507-1527. [Content Brief]
[3]. Dahmen AC, et al. Paucimannosidic glycoepitopes are functionally involved in proliferation of neural progenitor cells in the subventricular zone. Glycobiology. 2015;25(8):869-880. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Paucimannose Related Classifications
HY-N10631 Related Classifications
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