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Art. -Nr.: HY-116882

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PIK-39

PIK-39 is a selective PI3Kδ inhibitor with an IC₅₀ of 0.30 μM. PIK-39 has a propeller-like structure that induces conformational changes in the ATP-binding region of its target. PIK-39 is applicable to the research of autoimmune diseases.

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CAS. Nr.: 371242-53-4
Formel: C₂₁H₁₅ClN₆O₂S
Molecular Weight:450.90

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIK-39 Chemical Structure

CAS. Nr.: 371242-53-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

PI3Kδ

0.3 μM (IC₅₀)

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Chemical Information

CAS. Nr. 371242-53-4
Molecular Weight 450.90
Formel C₂₁H₁₅ClN₆O₂S
SMILES

O=C1N(C(CSC2=C3N=CNC3=NC=N2)=NC4=C1C(Cl)=CC=C4)C5=CC=CC=C5OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Cushing T D, et al. Discovery and in vivo evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl) quinolin-3-yl) ethyl)-9 H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease[J]. Journal of Medicinal Chemistry, 2015, 58(1): 480-511.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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- IC₅₀ & Target
Chemical Information
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PIK-39

Alle PI3K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

Chemical Information

Protokoll

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PIK-39 Related Classifications

HY-116882 Related Classifications

Bioz

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