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Art. -Nr.: HY-N21692

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Procumbenoside A

Procumbenoside A is a lignan glycoside discovered in Justicia procumbens. Procumbenoside A inhibits HIV-1 replication with an IC₅₀ of 4.95 μM. Procumbenoside A exerts cytotoxic effects on various cancer cells. Procumbenoside A induces Cu (II)-mediated strand breaks in supercoiled plasmid DNA, generating the relaxed circular DNA form, while no linear form is detected. Procumbenoside A is used in studies related to liver cancer, colon adenocarcinoma, and HIV-1 infection.

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CAS. Nr.: 408358-51-0
Formel: C₃₁H₃₂O₁₅
Molecular Weight:644.58

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Procumbenoside A Chemical Structure

CAS. Nr.: 408358-51-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

HIV-1

4.95 μM (IC₅₀)

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
NIH3T3	ED₅₀	3.1 μg/mL	Cytotoxic activity against 212 cells measured by MTT assay after 6 days of incubation. Cytotoxic activity against 212 cells measured by MTT assay after 6 days of incubation.	11908984
Hep 3B2	ED₅₀	3.1 μg/mL	Cytotoxic activity against human Hep 3B cells measured by MTT assay after 6 days of incubation. Cytotoxic activity against human Hep 3B cells measured by MTT assay after 6 days of incubation.	11908984
HepG2	ED₅₀	3.9 μg/mL	Cytotoxic activity against human Hep G2 cells measured by MTT assay after 6 days of incubation. Cytotoxic activity against human Hep G2 cells measured by MTT assay after 6 days of incubation.	11908984
HT-29	ED₅₀	6.7 μg/mL	Cytotoxic activity against human HT-29 cells measured by MTT assay after 6 days of incubation. Cytotoxic activity against human HT-29 cells measured by MTT assay after 6 days of incubation.	11908984
A549	CC₅₀	> 31.0 μM	Cytotoxicity against human A549 lung epithelial cells assessed by MTS assay at 48 h after initial compound addition following 24 h incubation with procumbenoside A, with the CC50 value greater than 31.0 μM. Cytotoxicity against human A549 lung epithelial cells assessed by MTS assay at 48 h after initial compound addition following 24 h incubation with procumbenoside A, with the CC50 value greater than 31.0 μM.	31882050

In Vitro

Procumbenoside A (6 days) exerts significant cytotoxic effects on 212, Hep 3B, Hep G2, and HT-29 cells, with ED₅₀ values of 3.1, 3.1, 3.9, and 6.7 µg/mL, respectively^[1].
Procumbenoside A (0.3125-10 μM; 24-48 h) inhibits the replication of HIV-1 pseudovirus in A549 human lung epithelial cells, with an IC₅₀ of 4.95 μM. It exhibits low cytotoxicity (CC₅₀ > 31.0 μM) and a selectivity index greater than 6.2^[2].
Procumbenoside A significantly induces Cu (II)-mediated concentration-dependent strand breaks in supercoiled pBR322 plasmid DNA, resulting in the formation of relaxed open-circle DNA^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

A549 human lung epithelial cells
Concentration:

0.3125, 0.625, 1.25, 2.5, 5 and 10 μM
Incubation Time:

24 h
Result:

Exhibited low cytotoxicity (CC₅₀> 31.0 μM).

Chemical Information

CAS. Nr. 408358-51-0
Molecular Weight 644.58
Formel C₃₁H₃₂O₁₅
SMILES

O=C1C2=C(C=3C(C(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O)CO5)[C@](CO)(O)CO4)=C2CO1)=CC(OC)=C(OC)C3)C=6C=C7C(=CC6)OCO7
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
- Plants
- Acanthaceae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Day SH, et al. Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages. Journal of natural products. 2002 Mar;65(3):379-81. [Content Brief]

[2]. Xu XY, et al. Anti-HIV lignans from Justicia procumbens. Chinese journal of natural medicines. 2019 Dec;17(12):945-952. [Content Brief]

[3]. Lu YH, et al. DNA strand-scission by phloroglucinols and lignans from heartwood of Garcinia subelliptica Merr. and Justicia plants. Phytochemistry. 2008 Jan;69(1):225-33. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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