CD160
CD160 (BY55) is a small glycosylphosphatidylinositol-anchored immunoglobulin superfamily receptor functioning as an inhibitory checkpoint on NK cells and T cells. CD160 is expressed on most circulating NK cells, CD8 T cells, γδ T cells and intestinal intraepithelial lymphocytes; its extracellular IgV-like domain binds classical and non-classical MHC class I molecules (HLA-A, HLA-B, HLA-C and HLA-E) with low affinity, as well as the herpesvirus entry mediator (HVEM). When engaged by HVEM, CD160 delivers inhibitory signals through an undefined intracellular cascade, suppressing CD4+ and CD8+ T-cell activation, IFN-γ and TNF-α secretion and NK cytotoxicity, thereby maintaining mucosal tolerance and limiting immunopathology in the gut; CD160 also acts as an MHC class I-recognizing activating receptor in NK-cell cytotoxicity under certain conditions. In chronic viral infection and tumors, CD160 marks exhausted CD8+ T cells and tumor-infiltrating lymphocytes, where its expression correlates with terminal differentiation. Soluble CD160 released by metalloprotease cleavage modulates endothelial angiogenic functions.
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CD160 Recombinant Proteins (9)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
