Sacibertinib
Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity.
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- CAS. Nr.: 1351941-69-9
- Formel: C32H31ClN6O4
- Molecular Weight:599.08
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Alle EGFR Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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EGFR-TK phosphorylation 110 nM (EC50) |
HER2 244 nM (EC50) |
Sacibertinib has inhibitory activity against Sk-Br-3, SW620 cells with GI50s of 3.8 nM and 1.78 μM, and against CCRF-CEM/T, Fadu, BxPc-3 and AsPC-1 with IC50s of 5.6 μM, 101 nM, 337 nM and 1 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1351941-69-9
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Molecular Weight 599.08
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Formel C32H31ClN6O4
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SMILES
CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)OCC3=CC=CC=N3)=C(C#N)C=N4)=C4C=C1O[C@H]5CCOC5)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Sacibertinib Related Classifications
HY-147303 Related Classifications
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