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Art. -Nr.: HY-126803

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Saquayamycin B

Saquayamycin B (compound 3) is a new angucycline antibiotic. Saquayamycin B has antitumor activities against a human lung (H-460) and a human breast cancer cell line (MCF-7) with GI₅₀ values of 12.2 and 15.2 µM respectively .

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CAS. Nr.: 99260-67-0
Formel: C₄₃H₄₈O₁₆
Molecular Weight:820.83

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Saquayamycin B Chemical Structure

CAS. Nr.: 99260-67-0

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Biologische Aktivität
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- Cellular Effect
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	GI₅₀	15.2 μM Compound: 3	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 18666798]
MCF7	GI₅₀	15.2 μmol Compound: 3	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 18666798]
NCI-H460	GI₅₀	12.2 μM Compound: 3	Cytotoxicity against human H460 cells after 48 hrs by SRB assay Cytotoxicity against human H460 cells after 48 hrs by SRB assay	[PMID: 18666798]
NCI-H460	GI₅₀	12.2 μmol Compound: 3	Cytotoxicity against human H460 cells after 48 hrs by SRB assay Cytotoxicity against human H460 cells after 48 hrs by SRB assay	[PMID: 18666798]
NCI-H460	GI₅₀	3.929 μM Compound: 8	Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay	[PMID: 22758660]
PC-3	GI₅₀	0.07454 μM Compound: 8	Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay	[PMID: 22758660]

Chemical Information

CAS. Nr. 99260-67-0
Molecular Weight 820.83
Formel C₄₃H₄₈O₁₆
SMILES

O=C1C[C@@](O[C@H]2CC[C@H](O[C@H]3C=CC([C@H](C)O3)=O)[C@H](C)O2)(C)C[C@]4(O)[C@@]1(O)C(C(C5=CC=C([C@H]6C[C@@]7([H])O[C@](CC([C@H](C)O8)=O)([H])[C@]8([H])O[C@]7([H])[C@@H](C)O6)C(O)=C5C9=O)=O)=C9C=C4
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces sp.
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mohamed S Abdelfattah, et al. Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002. J Nat Prod. 2008 Sep;71(9):1569-73. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Saquayamycin B

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Saquayamycin B Related Classifications

HY-126803 Related Classifications