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Art. -Nr.: HY-181828

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SePP

SePP is a blood-brain barrier-permeable NMDAR antagonist and dopamine/norepinephrine reuptake inhibitor, with a K_i of 28.7 nM for rat NMDAR. SePP exerts anticonvulsant effects. SePP can be used in research related to fragile X syndrome.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₇H₂₁NSe
Molecular Weight:318.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SePP Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

NMDA Receptor

28.7 nM (Ki)

Alle iGluR Isoform-spezifische Produkte anzeigen :

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

SePP (multiple concentrations; 2 h) potently binds to rat forebrain NMDARs with a K_i of 28.7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Plasma Concentration
Mice^[1]	10 mg/kg	i.p.	387.5 ng/mL

In Vivo

SePP (10 mg/kg; i.p.) completely suppresses audiogenic seizures in juvenile Fmr1 knockout mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

FVB.129P2-Pde6b+ Tyrc‑ch Fmr1tm1Cgr/J (Fmr1 knockout, 4 male and 4 female, postnatal day 23-25, audiogenic seizure induction)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; single dose
Result:

Abolished wild running and jumping (WRJ), tonic-clonic seizure (TCS), and respiratory arrest (RA) in all treated mice, with statistically significant differences compared to vehicle controls (P < 0.0001 for WRJ and TCS, P = 0.0013 for RA).
Exhibited normal behaviors including exploring, rearing, grooming, and interacting with cage-mates during testing.

Chemical Information

Molecular Weight 318.32
Formel C₁₇H₂₁NSe
SMILES

C1(CC(N2CCCCC2)C3=CC=C[Se]3)=CC=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wallach J, et al. Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome. J Med Chem. 2026;69(4):4020-4036. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

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SePP

Alle iGluR Isoform-spezifische Produkte anzeigen

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

SePP Related Classifications

HY-181828 Related Classifications