SR-16157
SR-16157 (NSC 732011; HLX-801) is a dual-action steroid sulfatase (STS) inhibitor (IC50 = 0.1 uM) and selective ERα modulator. SR-16157 exhibits STS inhibitory and anti-estrogenic effects in breast cancer cells. SR-16157 may be used in breast cancer research.
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- CAS. Nr.: 943344-76-1
- Formel: C27H44N2O4S
- Molecular Weight:492.71
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
100 nM
Compound: 15a; SR 16157
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Inhibition of estrone sulfatase in human MCF7 cells using [3H]-estrone sulphate as substrate incubated for 30 mins by liquid scintillation counting method
Inhibition of estrone sulfatase in human MCF7 cells using [3H]-estrone sulphate as substrate incubated for 30 mins by liquid scintillation counting method
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[PMID: 26974384] |
Chemical Information
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CAS. Nr. 943344-76-1
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Molecular Weight 492.71
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Formel C27H44N2O4S
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SMILES
O=S(OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](CCOCCN(CC)CC)CC[C@@]4([H])[C@]3([H])[C@H](C)CC2=C1)(N)=O
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Synonyms
NSC 732011; HLX-801
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SR-16157 Related Classifications
HY-123773 Related Classifications
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