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Art. -Nr.: HY-155070

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SRE-II

SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₅H₉ClINO₂
Molecular Weight:397.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SRE-II Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	1.31 μM Compound: SRE-II	Anticancer activity against mouse 4T1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay Anticancer activity against mouse 4T1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay	[PMID: 37119664]
MDA-MB-231	IC₅₀	1.59 μM Compound: SRE-II	Anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay Anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay	[PMID: 37119664]

Chemical Information

Molecular Weight 397.59
Formel C₁₅H₉ClINO₂
SMILES

O=C(C=C1)C2=CC=CC3=C(NC(CCl)=O)C(I)=CC1=C32
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Qiaoyun Jiang, et al. Lysosome-targeting phenalenones as efficient type I/II photosensitizers for anticancer photodynamic therapy. Eur J Med Chem. 2023 Jul 5;255:115418. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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