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Art. -Nr.: HY-146666

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STAT3-IN-9

STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase.

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CAS. Nr.: 2987726-27-0
Formel: C₂₂H₂₁N₃O₄
Molecular Weight:391.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

STAT3-IN-9 Chemical Structure

CAS. Nr.: 2987726-27-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

STAT3

Alle STAT Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.73 μM Compound: C6	Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay	[PMID: 33126089]
HCT-116	IC₅₀	>25 μM Compound: C6	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay	[PMID: 33126089]
HepG2	IC₅₀	1.63 μM Compound: C6	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay	[PMID: 33126089]
MDA-MB-231	IC₅₀	5.8 μM Compound: C6	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay	[PMID: 33126089]
MDA-MB-468	IC₅₀	0.16 μM Compound: C6	Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay	[PMID: 33126089]
U-251	IC₅₀	>25 μM Compound: C6	Antiproliferative activity against human U-251 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay Antiproliferative activity against human U-251 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay	[PMID: 33126089]

In Vitro

STAT3-IN-9 (compound C6) (48 h) shows potent in vitro anti-tumor activity with IC₅₀s of 0.16, 5.80, 1.63, 5.73, >25, >25 µM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively^[1].
STAT3-IN-9 (0, 0.2, 1.0, 5.0 µM; 24 h) inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701)^[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces apoptosis through the mitochondrial Caspase dependent apoptotic pathway^[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces cell cycle arrest at the G2/M phase in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells
Concentration:
Incubation Time:

48 h
Result:

Showed potent in vitro anti-tumor activity with IC₅₀s of 0.16, 5.80, 1.63, 5.73, >25, >25 µM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-468 cells
Concentration:

0, 0.2, 1.0, 5.0 µM
Incubation Time:

24 h
Result:

Inhibited the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701).

Apoptosis Analysis^[1]

Cell Line:

MDA-MB-468 cells
Concentration:

0, 0.2, 1 µM
Incubation Time:

24 h
Result:

Induced apoptosis through the mitochondrial Caspase dependent apoptotic pathway.

Cell Cycle Analysis^[1]

Cell Line:

MDA-MB-468 cells
Concentration:

0, 0.2, 1 µM
Incubation Time:

24 h
Result:

Cells were arrest at the G2/M phase in a dose-dependent manner.

Chemical Information

CAS. Nr. 2987726-27-0
Molecular Weight 391.42
Formel C₂₂H₂₁N₃O₄
SMILES

COC1=CC(NC2=CC(C3=CC=NN3C)=CC4=C2OC(C(C)=O)=C4)=CC(OC)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang F, et al. Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study. Bioorg Med Chem. 2020; 28(24):115822. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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STAT3-IN-9

Alle STAT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

STAT3-IN-9 Related Classifications

HY-146666 Related Classifications