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Art. -Nr.: HY-P99575

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Biologically Validated

Tarlatamab

Name: Tarlatamab
Brand: MedChemExpress
SKU: HY-P99575
Price: 750.00 USD
Availability: InStock
Rating: 5 (5 reviews)

(Synonyms: AMG 757)

5 Cited Publications

Kundenbewertung

Based on 5 publication(s) in Google Scholar

Tarlatamab (AMG 757) is a bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3). DLL3 is a target that is selectively expressed in small-cell lung cancer (SCLC) tumors, but with minimal normal tissue expression. Tarlatamab has the K_Ds of 0.64 nM and 0.50 nM for human and nonhuman primate (NHP) DLL3, respectively. Tarlatamab has the K_Ds of 14.9 nM and 12 nM for human and NHP CD3, respectively. Tarlatamab is a first-in-class HLE BiTE immuno-oncology therapy targeting DLL3 and has the potential for SCLC research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.77%
CAS. Nr.: 2307488-83-9
Molecular Weight:105.07 kDa

Speicherung:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Tarlatamab Chemical Structure

CAS. Nr.: 2307488-83-9

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Preis

Verfügbarkeit

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Publications (5)
Reinheit & Dokumentation
Verweise
Hot Topics (1)
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

(scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc

Species Reactivity

Human

IC₅₀ & Target

CD3E & DLL3

In Vitro

Tarlatamab (AMG 757; 0-10 nM; 48 hours) has potent, specific cytotoxic activity against DLL3-expressing SCLC cell lines in vitro^[1].
Tarlatamab (0-10 nM; 4-72 h) increased granzyme B levels and cytotoxicity over time, with maximal signal observed at 48 hours. Markers of T-cell activation or inflammation, CD69, CD71, PD-1, and PD-L1 (37-39) were upregulated^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SCLC cell lines (DMS 79, NCI-H2171, NCI-H889, SHP-77, NCI-H211,COR-L279)
Concentration:

0-10 nM
Incubation Time:

48 hours
Result:

AMG 757 effectively engaged human T cells to kill SCLC cell lines, including those with very low DLL3 expression levels.

In Vivo

Tarlatamab (AMG 757; 3 mg/kg; IP; once weekly for 3 weeks) drives tumor regression in mouse models of SCLC^[1].
Tarlatamab (IP; 12 μg/kg; single dose) has a mean half-life of 234 hours (9.8 days), a mean clearance of 0.487 mL/hour/kg and a steady-state volume of distribution of 146 mL/kg in nonhuman primates (NHPs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female NOD.Cg-PrkdcscidIl2rgtm1Sug/JicTac (NOG) mice with patient-derived SCLC tumor fragments (LXFS 1129 and LXFS 538)^[1]
Dosage:

3 mg/kg
Administration:

IP; once weekly for 3 weeks
Result:

Led to 83% tumor regression and an overall significant reduction in tumor volume compared with that in mice which received a control HLE BiTE molecule in the LXFS 1129 model.
Induced 98% tumor regression in the LXFS 538 model.

Related Protocols :

RNA extraction experimental

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

916 [NCBI] & 10683 [NCBI]

Accession

P07766 & Q9NYJ7

Conjugated

Unconjugated

Reconstitution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

(scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Flow cytometry analysis of Jurkat cells labelling CD3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
Flow cytometry analysis of DLL3 overexpression HEK293 cells labelling DLL3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Red).

Chemical Information

CAS. Nr. 2307488-83-9
Appearance Liquid
Molecular Weight 105.07 kDa
Color Colorless to light yellow
SMILES

[Tarlatamab]
Synonyms

AMG 757
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

All

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Journal Impact Factor

SSRN

2026 Sep 30.
bioRxiv

2026 Aug 20.
bioRxiv

2026 Jul 17.
bioRxiv

Transcription Factor Subtype Governs Response and Resistance to DLL3-Directed T-Cell Engagement in Small Cell Lung Cancer. [Abstract]

2026 Apr 8:2026.04.02.715020. PMID: 41993528
bioRxiv

2025 Aug 15.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Michael J Giffin, et al. AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer. Clin Cancer Res. 2021 Mar 1;27(5):1526-1537. [Content Brief]

Hot Topics

Type:

All

Sort by:

Most Recent

Topics TCE (T cell engager) Potential in Solid Tumors
T-cell engagers (TCEs) are engineered immunotherapeutic molecules designed to redirect endogenous T cells toward tumor cells through simultaneous binding of a T-cell receptor component, most commonly CD3, and a tumor-associated antigen (TAA) expressed on malignant cells.

2026-06-18

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Tarlatamab

5 Cited Publications

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Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- Anwendung
- Biological Activity
Chemical Information
Publications (5)
Reinheit & Dokumentation
Verweise

1/16

(scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc
1/16

Flow cytometry analysis of Jurkat cells labelling CD3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
1/16

Flow cytometry analysis of DLL3 overexpression HEK293 cells labelling DLL3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Red).
1/16

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Tarlatamab

Publications Citing Use of MedChemExpress (MCE) Tarlatamab