UNC10062
UNC10062 is a dopamine D1 receptor (D1R) positive allosteric modulator. UNC10062 specifically binds to the extracellular allosteric pocket (upper pocket) at the interface of transmembrane helices (TM) 1 and 7 of D1R. UNC10062 can increase dopamine potency and D1R-mediated cAMP production. UNC10062 can be used for the research of neurological disease, such as Parkinson's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C20H23N3O4S
- Molecular Weight:401.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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D1 Receptor |
UNC10062 (50 μM, 90 mins) increases dopamine potency in CHO-K1 cells stably expressing D1R, with an E C50 fold-shift of 3.9[1].
UNC10062 (25-50 μM, 5 mins) synergistically enhances D1R-mediated cAMP production in HEK293 cells when combined with LY3154207 (HY-128770) and BMS-A1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 401.48
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Formel C20H23N3O4S
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SMILES
CC(C)(C1CCC2=C(SC(NC(C3=CC=NC=C3)=O)=C2C(N)=O)C1)C(OC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
UNC10062 Related Classifications
HY-179241 Related Classifications
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