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Art. -Nr.: HY-158046

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UNC8899

UNC8899 is a STING PROTAC degrader with a DC₅₀ of 1.097 μM. UNC8899 recruits the VHL E3 ligase to mediate the ubiquitination of phosphorylated STING and subsequent proteasomal degradation. UNC8899 can be used in studies of renal cell carcinoma.
(Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3094059-37-4
Formel: C₇₁H₉₁N₁₇O₁₃S
Molecular Weight:1422.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

UNC8899 Chemical Structure

CAS. Nr.: 3094059-37-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
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Biologische Aktivität

Beschreibung

UNC8899 is a STING PROTAC degrader with a DC₅₀ of 1.097 μM. UNC8899 recruits the VHL E3 ligase to mediate the ubiquitination of phosphorylated STING and subsequent proteasomal degradation. UNC8899 can be used in studies of renal cell carcinoma^[1]. (Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

IC₅₀ & Target

^[1]

VHL

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

UNC8899 (0-31.6 μM；24 h) degrades STING in Caki-1 cells, with a DC50 of 1.097 μM and a Dmax of 99.94%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Caki-1
Concentration:

0.01, 0.0316, 0.1, 0.316, 1, 3.16, 10, 31.6 μM
Incubation Time:

24 h
Result:

Degraded STING in Caki-1 cells, with a DC₅₀ of 1.097 μM and a D_max of 99.94%.

Chemical Information

CAS. Nr. 3094059-37-4
Molecular Weight 1422.65
Formel C₇₁H₉₁N₁₇O₁₃S
SMILES

O=C(NCCOCCOCCC(N[C@@H](C(N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](C1)O)=O)C(C)(C)C)=O)C4=CC5=C(C(OC)=C4)N(C/C=C/CN6C(NC(C7=CC(C)=NN7CC)=O)=NC8=C6C(OCCCN9CCOCC9)=CC(C(N)=O)=C8)C(NC(C%10=CC(C)=NN%10CC)=O)=N5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhu Z, et al. Development of VHL-recruiting STING PROTACs that suppress innate immunity. Cellular and molecular life sciences : CMLS. 2023 May 14;80(6):149. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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- In Vitro
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UNC8899

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

UNC8899 Related Classifications

HY-158046 Related Classifications

Bioz

Keywords

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