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Art. -Nr.: HY-119612

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XCT0135908

(Synonyms: XCT)

XCT0135908 (XCT) is a selective Nurr1-RXRα activator with an EC₅₀ value of 0.3 μM in human dopaminergic SH-SY5Y cells. XCT0135908 protects dopaminergic cells against the Parkinson’s disease-related toxin MPP⁺. XCT0135908 can be used for the research of Parkinson’s disease.

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CAS. Nr.: 300837-31-4
Formel: C₂₁H₁₉N₃O₂
Molecular Weight:345.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

XCT0135908 Chemical Structure

CAS. Nr.: 300837-31-4

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

Alle Nuclear Hormone Receptor 4A/NR4A Isoform-spezifische Produkte anzeigen :

Alle RAR/RXR Isoform-spezifische Produkte anzeigen :

In Vitro

XCT0135908 (Compound 7a) (0.5-12.5 μM; overnight) activates the Nurr1-RXRα heterodimer in human dopaminergic SH-SY5Y cells with an EC₅₀ of 0.3 μM^[1].
XCT0135908 (0.5-12.5 μM; 12 h) selectively activates Nurr1-RXRα and Nur77-RXRα heterodimers (but not other RXRα heterodimers or homodimers) in human dopaminergic SH-SY5Y cells, with greater activation of Nur77GAL4-RXRαVP16 than Nurr1GAL4-RXRαVP16^[1].
XCT0135908 (12.5-50 μM) protects mouse Neuro-2a neuroblast cells from MPP⁺-induced toxicity at concentrations of 12.5 μM and 50 μM, with no observed toxicity at 50 μM^[1].
XCT0135908 (0.5-12.5 μM; 24 h) induces a moderate concentration-dependent increase in SREBP-1c expression in human HepG2 hepatic cells, with a maximal ~5-fold increase at 12.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

human HepG2 hepatic cells
Concentration:

0.5 μM; 12.5 μM
Incubation Time:

24 h
Result:

Triggered a concentration-dependent increase in SREBP-1c expression.
Induced a maximal increase of ~5-fold over controls.

Chemical Information

CAS. Nr. 300837-31-4
Molecular Weight 345.40
Formel C₂₁H₁₉N₃O₂
SMILES

O=C(O)C1=CC=C(C=C1)NC2=NC(=NC(=C2CC=C)C)C=3C=CC=CC3
Synonyms

XCT
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Asvos X, et al. BRF110, an Orally Active Nurr1-RXRα-Selective Rexinoid, Enhances BDNF Expression without Elevating Triglycerides. J Med Chem. 2025;68(4):4763-4786. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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Biologische Aktivität
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- In Vitro
Chemical Information
Reinheit & Dokumentation
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XCT0135908

Alle Nuclear Hormone Receptor 4A/NR4A Isoform-spezifische Produkte anzeigen

Alle RAR/RXR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

XCT0135908 Related Classifications

HY-119612 Related Classifications