country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-176555

Copy Link Print Information

Z169667518

Z169667518 is an IL-6 inhibitor. Z169667518 inhibits IL-6-induced STAT3 reporter gene signaling.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 941127-19-1
Formel: C₂₃H₁₈N₄O
Molecular Weight:366.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Z169667518 Chemical Structure

CAS. Nr.: 941127-19-1

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Z169667518 is an IL-6 inhibitor. Z169667518 inhibits IL-6-induced STAT3 reporter gene signaling^[1].

IC₅₀ & Target

^[1]

IL-6

STAT3

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Alle STAT Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC50	2.7 μM	Inhibition of IL6-induced STAT3 luciferase reporter activity in HEK293T cells assessed after 5 hrs exposure by dual-luciferase reporter assay. Inhibition of IL6-induced STAT3 luciferase reporter activity in HEK293T cells assessed after 5 hrs exposure by dual-luciferase reporter assay.	40733185

In Vitro

Z169667518 (10 µM; 5 h) inhibits IL6-induced STAT3 reporter activity in HEK293T cells, producing ~84% inhibition at 10 µM and an IC₅₀ of 2.7 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 941127-19-1
Molecular Weight 366.42
Formel C₂₃H₁₈N₄O
SMILES

O=C(C1=CC=C(C=C1)C#CC2=CC=CC=C2)NCCC3=NN=C4C=CC=CN43
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Joshi A, et al. Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6. Molecules. 2025 Jul 10;30(14):2919. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Z169667518

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Alle STAT Isoform-spezifische Produkte anzeigen