ESI-08
Based on 1 publication(s) in Google Scholar
ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation.
For research use only. We do not sell to patients.
- Purity: 98.74%
- CAS No.: 301177-43-5
- Formula: C20H23N3OS
- Molecular Weight:353.48
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) ESI-08
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Biological Activity
Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 301177-43-5
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Appearance Solid
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Molecular Weight 353.48
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Formula C20H23N3OS
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Color White to off-white
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SMILES
N#CC1=C(C2CCCCC2)N=C(SCC3=CC(C)=CC=C3C)NC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (282.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8290 mL | 14.1451 mL | 28.2901 mL | 70.7254 mL |
| 5 mM | 0.5658 mL | 2.8290 mL | 5.6580 mL | 14.1451 mL | |
| 10 mM | 0.2829 mL | 1.4145 mL | 2.8290 mL | 7.0725 mL | |
| 15 mM | 0.1886 mL | 0.9430 mL | 1.8860 mL | 4.7150 mL | |
| 20 mM | 0.1415 mL | 0.7073 mL | 1.4145 mL | 3.5363 mL | |
| 25 mM | 0.1132 mL | 0.5658 mL | 1.1316 mL | 2.8290 mL | |
| 30 mM | 0.0943 mL | 0.4715 mL | 0.9430 mL | 2.3575 mL | |
| 40 mM | 0.0707 mL | 0.3536 mL | 0.7073 mL | 1.7681 mL | |
| 50 mM | 0.0566 mL | 0.2829 mL | 0.5658 mL | 1.4145 mL | |
| 60 mM | 0.0472 mL | 0.2358 mL | 0.4715 mL | 1.1788 mL | |
| 80 mM | 0.0354 mL | 0.1768 mL | 0.3536 mL | 0.8841 mL | |
| 100 mM | 0.0283 mL | 0.1415 mL | 0.2829 mL | 0.7073 mL |
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