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Carnosol

17 Cited Publications
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Based on 17 publication(s) in Google Scholar

Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1).

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  • Pureté: 98.79%
  • CAS No.: 5957-80-2
  • Formule: C20H26O4
  • Masse moléculaire:330.42
  • Stockage:
    Powder   -20°C, 3 years

    * The compound is unstable in solutions, freshly prepared is recommended.

  • Carnosol Chemical Structure
    Carnosol Chemical Structure
  • Experimental Validation Results for Carnosol
  • Experimental Validation Results for Carnosol
  • Experimental Validation Results for Carnosol
  • Experimental Validation Results for Carnosol
  • Experimental Validation Results for Carnosol
  • Experimental Validation Results for Carnosol
  • Experimental Validation Results for Carnosol
CAS No.: 5957-80-2
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  • Carnosol Chemical Structure
    Carnosol Chemical Structure
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    Carnosol purchased from MedChemExpress. Usage Cited in: Int J Surg. 2025 Jul 9. [Abstract]

    Customer Validation
     Carnosol (200 mg/kg i.p. injection every 3 days). Combined application of CytoTRACE to dissect HMOX1_malignant+ and HMOX1_malignant− cells. (E) Tumor growth in ID8 tumor-bearing mice treated with saline, IgG, αPD-1, carnosol or αPD-1 + carnosol (n = 8 mice/group). Tumor growth was monitored by measuring the tumor volume for 2 weeks.

  • 1/16

    Carnosol purchased from MedChemExpress. Usage Cited in: Int J Surg. 2025 Jul 9. [Abstract]

    Customer Validation
     Carnosol (200 mg/kg i.p. injection every 3 days). Tumor growth in mice bearing ID8, Mice were given saline, IgG, αPD-1, carnosol, IMD0354, carnosol + αPD-1, IMD0354 + αPD-1 or carnosol + IMD0354 + αPD-1. N = 8 mice/group. Tumor growth was monitored by measuring the tumor volume for 2 weeks.

  • 1/16

    Carnosol purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118397. [Abstract]

    Customer Validation
     Minced gastrocnemius muscles from six-month-old C57BL/6 male mice were mixed with ethanol (0.01 %; solvent; CTRL), BHT (positive control), carnosol (CO), rosmanol (ROS), isoromanol (ISOR), dimethylcarnosol (DCO) or dimethylisorosmanol (DISOR), all dissolved in ethanol and mixed at 0.01 % w/w minced muscle. At day 0 and day 7 of refrigerated storage (+4 °C), lipid oxidation was evaluated by TBARS quantification.

  • 1/16

    Carnosol purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118397. [Abstract]

    Customer Validation
     Carnosol (CO, 48 h at 10 μM). Human myotubes treated for 36 h with 10 μM of carnosol analogues or DMSO (Solvent; CTRL) prior to incubation with sub-lethal concentration of 100 μM H2O2 for one hour. Western blot analysis of phosphorylated γH2AX protein level.

  • 1/16

    Carnosol purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118397. [Abstract]

    Customer Validation
     Carnosol (CO, 48 h at 10 μM). Differentiated myoblasts were treated or not (CTRL; 0.1 % DMSO) with CO, ROS, ISOR, DCO and DISOR, at a concentration of 10 μM. Two days later, myotubes were processed for indirect immunofluorescence analysis with an antibody against troponin T (green). Nuclei were visualized by DAPI staining (blue). Representative images.

  • 1/16

    Carnosol purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118397. [Abstract]

    Customer Validation
     Carnosol (CO, 48 h at 10 μM). In parallel, myotube protein extracts were analyzed by western blotting with anti-Muscle Ring-Finger Protein-1 (MuRF1; TRIM 63) antibody (green). Revert® total protein stain was used as internal loading control (red).

  • 1/16

    Carnosol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 28;13(7):653. [Abstract]

    Customer Validation
     Survival analysis of the indicated mice in CLP-induced sepsis with or without treatment of 10 mg/kg HET0016, 20 mg/kg JSH-23, or 10 mg/kg Carnosol at 2 h before CLP and 12, 24, 48, and 72 h after CLP (n = 15 per group).

  • Carnosol