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Dioscin

(Synonyms: Collettiside III; CCRIS 4123)
11 Cited Publications
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Based on 11 publication(s) in Google Scholar

Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity.

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  • Pureté: 99.95%
  • CAS No.: 19057-60-4
  • Formule: C45H72O16
  • Masse moléculaire:869.04
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Dioscin Chemical Structure
    Dioscin Chemical Structure
  • Experimental Validation Results for Dioscin
  • Experimental Validation Results for Dioscin
  • Experimental Validation Results for Dioscin
  • Experimental Validation Results for Dioscin
  • Experimental Validation Results for Dioscin
  • Experimental Validation Results for Dioscin
  • Experimental Validation Results for Dioscin
  • Experimental Validation Results for Dioscin
CAS No.: 19057-60-4
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  • Dioscin Chemical Structure
    Dioscin Chemical Structure
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    Dioscin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Nov 11.

    Customer Validation
     Dioscin (200 nM, 24 h) alleviates gout by inhibiting hypoxia-inducible factor 1-alpha (HIF-1α) in CD4+ T cells. Quantitative PCR analysis revealing significantly elevated mRNA levels of HIF-1α after DIO treatment (n = 3).

  • 1/16

    Dioscin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Nov 11.

    Customer Validation
     Dioscin (200 nM, 24 h) alleviates gout by inhibiting hypoxia-inducible factor 1-alpha (HIF-1α) in CD4+ T cells. Western blot analysis revealing significantly elevated protein levels of HIF-1α after DIO treatment (n = 3).

  • 1/16

    Dioscin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Nov 11.

    Customer Validation
     Representative images and hematoxylin and eosin (H&E) analysis of footpads after IOX4 and Dioscin (20 mg/kg, intraperitoneal injection weekly over a six-week period) treatment (n = 3).

  • 1/16

    Dioscin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Nov 11.

    Customer Validation
     Pull-down analysis between Dioscin (200 nM, 24 h) and HIF-1α in primary CD4+ T cells (n = 3).

  • 1/16

    Dioscin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Nov 11.

    Customer Validation
     Dioscin (20 mg/kg, intraperitoneal injection weekly over a six-week period) reshapes CD4+ T cell differentiation via hypoxia-inducible factor 1-alpha (HIF-1α). T helper 17 (Th17) cell proportions in the blood, intestine, and spleen of DIO-treated urate oxidase (Uox)-knockout (KO) mice (n = 8).

  • 1/16

    Dioscin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Nov 11.

    Customer Validation
     Dioscin (20 mg/kg, intraperitoneal injection weekly over a six-week period) reshapes CD4+ T cell differentiation via hypoxia-inducible factor 1-alpha (HIF-1α). Multiplex immunofluorescence staining of Th17 cells in the footpad of DIO-treated Uox-KO mice (n = 3): representative images and quantitative analysis of Th17 cell numbers.

  • 1/16

    Dioscin purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Apr:117:109839. [Abstract]

    Customer Validation
     Dioscin-Medium group (5 mg/kg; p.o.; every-two days for 12 weeks) profoundly inhibits the phosphorylation of NF-ĸB in mice (Fig H and I). Dioscin-Low (Dio-L, 2.5 mg/kg), Dioscin-Medium (Dio-M, 5 mg/kg) and Dioscin-High (Dio-H, 10 mg/Kg).

  • 1/16

    Dioscin purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2017 Oct;16(4):4922-4926. [Abstract]

    Customer Validation
     Dioscin concentrations of 0.5, 1, 5, 10 and 25 µg/mL promotes the expression of ALP and inhibits the expression of LC3B in MC3T3-E1 cells, in a concentration-dependent manner.

  • Dioscin