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Etomoxir

(Synonyms: (R)-(+)-Etomoxir)
147 Cited Publications
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Based on 147 publication(s) in Google Scholar

Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

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  • Pureté: 99.58%
  • CAS No.: 124083-20-1
  • Formule: C17H23ClO4
  • Masse moléculaire:326.82
  • Stockage:

    -20°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

  • Etomoxir Chemical Structure
    Etomoxir Chemical Structure
  • Experimental Validation Results for Etomoxir
  • Experimental Validation Results for Etomoxir
  • Experimental Validation Results for Etomoxir
  • Experimental Validation Results for Etomoxir
  • Experimental Validation Results for Etomoxir
  • Experimental Validation Results for Etomoxir
  • Experimental Validation Results for Etomoxir
CAS No.: 124083-20-1
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  • Etomoxir Chemical Structure
    Etomoxir Chemical Structure
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    Etomoxir purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2025 Apr 22:S1535-6108(25)00138-2. [Abstract]

    Customer Validation
     Relative confluence of A375 cells treated with young secretome (YA, blue) and YA secretome containing Etomoxir (10 µM; 40 h) (YA Etomoxir, white circles).

  • 1/16

    Etomoxir purchased from MedChemExpress. Usage Cited in: Nat Genet. 2025 Mar;57(3):680-693. [Abstract]

    Customer Validation
     A375 cells treated with IFN-γ and Etomoxir (100,200 μM; 24 h) were analyzed for PD-L1 expression.

  • 1/16

    Etomoxir purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Sep 30. [Abstract]

    Customer Validation
     Luminescence detection of intracellular ATP (a.u., arbitrary units) in cultured hippocampal E16 Ddhd2−/− neurons ±1 µM M-CoA for 48 h and ± etomoxir (1 μM; 48 h) analysed at DIV 21–22 normalized to the average of Ddhd2−/− in each experiment.

  • 1/16

    Etomoxir purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 May 7;36(5):969-983.e10. [Abstract]

    Customer Validation
     Etomoxir (10 mM; 20 min). Energetic profiling, OCR trace with SRC quantifications of OT-1 T cells cultured ± ACCi.

  • 1/16

    Etomoxir purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Dec 5;35(12):2136-2152.e9. [Abstract]

    Customer Validation
     Etomoxir（50 μM; 6 days）.Seahorse respirometry and measurement of the oxygen consumption rate (OCR) in WT (D and F) or Lepr-cKO (E) nerve explants.

  • 1/16

    Etomoxir purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 15;14(2):125. [Abstract]

    Customer Validation
     Etomoxir reduces the proliferation of 143b cells.

  • 1/16

    Etomoxir purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Oct 11;7(41):67071-67086. [Abstract]

    Customer Validation
     MDA-MB-453 cells are treated as indicated for 2 days and subjected to immunoblotting. Combination treatments using non-saturating doses of Etomoxir and MTI-31 or Rapamycin results in an enhanced growth suppression in MDA-MB-453 cells, which is not readily observed in MDA-MB-231 cells, correlating a nearly complete suppression of cyclin D1 and c-Myc level in MDA-MB-453 cells under the combination treatments.

  • Etomoxir