AGN-190851
AGN-190851 is a potent and selective agonist of α2-adrenergic receptor (α2 adrenoceptor). AGN-190851 induces dose-dependent water diuresis in rats, and inhibits vasopressin V2 receptor in a species-dependent manner in vitro, thereby suppressing cAMP production. AGN-190851 enhances the contraction of porcine myometrium. AGN 190851 can be used in studies on renal diuretic mechanisms, pharmacology of α2-adrenergic receptor subtypes, and parturition.
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- CAS No.: 134892-42-5
- Formule: C11H14BrN5
- Masse moléculaire:296.17
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Alpha-2A adrenergic receptor |
V2 Receptor |
AGN-190851 dose-dependently inhibits vasopressin-stimulated cyclic AMP accumulation in rat cortical collecting tubules in vitro, but does not inhibit vasopressin-stimulated adenylate cyclase activity in dog cortical collecting tubules in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AGN-190851 (0.06-0.1 mg/kg; i.m.; single dose administered 20 h after intramuscular PGF2α 10 mg/sow) combined with prostaglandin F2α reduces the interval from treatment to farrowing in pregnant sows[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Landrace-Yorkshire sows (2 to 13 parities, mean 5.2 parities; 170 to 270 kg, mean 206 kg)[2]
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Dosage:0.06 mg/kg; 0.1 mg/kg
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Administration:i.m.; single dose (administered 20 h after intramuscular prostaglandin F2α 10 mg/sow)
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Result:Reduced the mean interval from second treatment to farrowing to 3.0 h at 0.06 mg/kg and 2.1 h at 0.1 mg/kg.
Lowered the mean stillbirth rate to 12.1% at 0.06 mg/kg and 3.9% at 0.1 mg/kg.
Required manual farrowing assistance in 2/20 sows at 0.06 mg/kg and 3/20 sows at 0.1 mg/kg.
Induced vomiting in 7/20 sows at 0.06 mg/kg and 11/20 sows at 0.1 mg/kg.
Chemical Information
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CAS No. 134892-42-5
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Masse moléculaire 296.17
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Formule C11H14BrN5
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SMILES
BrC1=C2NCCNC2=CC=C1/N=C3NCCN/3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Brooks DP, et al. The water diuretic effect of the alpha-2 adrenoceptor agonist, AGN 190851, is species-dependent. J Pharmacol Exp Ther. 1991;259(3):1277-1282. [Content Brief]
[2]. Yang PC, et al. Farrowing induction with a combination of prostaglandin F(2alpha) and a peripherally acting alpha(2)--adrenergic agonist AGN 190851 and a combination of prostaglandin F(2alpha) and oxytocin. Theriogenology. 1996 Nov 1;46(7):1289-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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