BIO-7488
Based on 1 Customer Validation
BIO-7488 is an orally active, selective and blood-brain barrier permeable IRAK4 inhibitor, with an IC50 value of 0.5 nM. BIO-7488 inhibits the production of pro-inflammatory cytokines (IL-1β, TNFα, IL-6) and demonstrates anti-inflammatory effects in both LPS (HY-D1056) and distal hypoxic-middle cerebral artery occlusion (DH-MCAO) ischemic stroke model. BIO-7488 can be used for the study of neuroinflammatory-related diseases, particularly ischemic stroke.
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- Pureté: 99.44%
- CAS No.: 2573211-25-1
- Formule: C23H25N7O3
- Masse moléculaire:447.49
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Kinase Inhibitor Library
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CNS-Penetrant Compound Library
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Pyroptosis Compound Library
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Orally Active Compound Library
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Anti-Prostate Cancer Compound Library
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Cancer Stem Cells Compound Library
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Pain-Related Compound Library
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Highly Selective Inhibitors Library
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Serine/Threonine Kinase Inhibitor Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Anti-Rheumatic Arthritis Compound Library
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Cardiotoxic Compound Library
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Posttranslational Modification Library
HY-L226
Activité biologique
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hIRAK4 0.5 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS (0.5 mg/kg) was intraperitoneally injected into 12-week-old female C57BL/6 mice or 16-week-old male C57BL/6 mice underwent distal middle cerebral artery cauterization surgery, followed by maintenance in a hypoxic environment for 1 hour[1]
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Dosage:10, 30, 100 mg/kg
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Administration:p.o., once
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Result:Reduced plasma IL-1β and TNFα levels.
Chemical Information
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CAS No. 2573211-25-1
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Appearance Solid
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Masse moléculaire 447.49
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Formule C23H25N7O3
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Color Light yellow to yellow
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SMILES
CC1(C2)OCC2(C1)C3=CN4C(N=C(OC(C)C)C(C(NC5=C(N=CC(C)=C6)N6N=C5)=O)=C4)=N3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 2 mg/mL (4.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2347 mL | 11.1734 mL | 22.3469 mL | 55.8672 mL |
BIO-7488 Related Classifications
HY-162359 Related Classifications
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