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Cat. No.: HY-179116

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BL-1005

(Synonyms: BS2463)

BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC₅₀ of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC₅₀ >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection.

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Formule: C₁₉H₁₇ClF₂N₄OS
Masse moléculaire:422.88

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

BL-1005 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

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In Vitro

BL-1005 (0.02-50 μM; 48 h) reduces cell viability in HEK293, HeLa and HepG2 cells with a CC₅₀ of 37.3, 21.3 and 22.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Note	C_max	T_1/2
Mice	2.5 mg/kg	i.p.	文献审核	247.3 ng/mL	1.51 h

In Vivo

BL-1005 (0.6-1.2 μM; 2 h) induces a sustained paralysis in both adult and juvenile S. mansoni^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Schistosoma mansoni (adult and juvenile, 28-42-day-old)^[1]
Dosage:

0.6 μM, 1.2 μM
Administration:

2 h
Result:

Induced a sustained paralysis in both adult and juvenile S. mansoni, with partial recovery of motility over 9 days.

Chemical Information

Masse moléculaire 422.88
Formule C₁₉H₁₇ClF₂N₄OS
SMILES

FC(C=C(C=C1F)N)=C1C(C(Cl)=NC(C2=CC=CS2)=N3)=C3NCC4(C)COC4
Synonyms

BS2463
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Francisco KR, et al. Structure-Activity Relationship and Target Investigation of Thiophen-2-yl-Pyrimidines against Schistosoma species. bioRxiv [Preprint]. 2025 Oct 8:2025.10.07.681061. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Quantité:
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BL-1005

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BL-1005 Related Classifications

HY-179116 Related Classifications