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Cat. No.: HY-137135

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Cantharidic acid

Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway.

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CAS No.: 28874-45-5
Formule: C₁₀H₁₄O₅
Masse moléculaire:214.22

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Cantharidic acid Chemical Structure

CAS No.: 28874-45-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform ERK :

Voir tous les produits spécifiques à Isoform p38 MAPK :

Voir tous les produits spécifiques à Isoform JNK :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	218.5 μM Compound: 4	Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33454654]
HL-60	IC₅₀	103.2 μM Compound: 4	Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33454654]
KB 3-1	IC₅₀	79.2 μM Compound: 4	Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33454654]
leukaemia cell line	IC₅₀	>50 μM Compound: 4	Anticancer activity against human leukaemia cell line assessed as cell growth inhibition Anticancer activity against human leukaemia cell line assessed as cell growth inhibition	[PMID: 33454654]

Chemical Information

CAS No. 28874-45-5
Masse moléculaire 214.22
Formule C₁₀H₁₄O₅
SMILES

OC([C@@]([C@@]1(C)C(O)=O)([C@@H]2O[C@H]1CC2)C)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen YC, et al., Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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Cantharidic acid

Voir tous les produits spécifiques à Isoform ERK

Voir tous les produits spécifiques à Isoform p38 MAPK

Voir tous les produits spécifiques à Isoform JNK