Clebopride
Based on 1 publication(s) in Google Scholar
Clebopride is an orally active dopamine Receptor antagonist. Clebopride acts on dopamine D2 receptors and has antiemetic and prokinetic effects. Clebopride can be used in the study of functional gastrointestinal disorders.
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- CAS No.: 55905-53-8
- Formule: C20H24ClN3O2
- Masse moléculaire:373.88
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Clebopride
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Activité biologique
Clebopride (0.1 nM-10μM, 30 min) selectively binds to D2 dopamine receptors (Ki: 3.5 nM) and α2 adrenergic receptors (Ki: 780 nM) in bovine brain membranes[3].
Clebopride inhibits ETS-induced gastric strip contractions (IC50: 0.43 μM) [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 55905-53-8
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Masse moléculaire 373.88
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Formule C20H24ClN3O2
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SMILES
O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(N)C=C3OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Metab
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. [Abstract]2022 Mar 1;34(3):424-440.e7. PMID: 35150639
Pureté et documentation
Références
[1]. Reis-Carneiro D, et al. Clebopride-Associated Movement Disorders. Mov Disord Clin Pract. 2023 Sep 6;10(10):1562-1563. [Content Brief]
[2]. Elliott PN, et al. Substituted benzamides as cerebral dopamine antagonists in rodents. Neuropharmacology. 1977 May;16(5):333-42. [Content Brief]
[3]. Takeda K, et al. Clebopride enhances contractility of the guinea pig stomach by blocking peripheral D2 dopamine receptor and alpha-2 adrenoceptor. J Pharmacol Exp Ther. 1991 May;257(2):806-11. [Content Brief]
[4]. Segura J, et al. The pharmacokinetics of a new benzamide drug clebopride, in the rat and the dog. J Pharm Pharmacol. 1981 Apr;33(4):214-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Clebopride Related Classifications
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