CliMB-325
CliMB-325 is an HSP90 inhibitor that can induce MHC-I (EC50 = 498 nM) expression on the surface of CT26 murine colorectal cancer cells. CliMB-325 enhances T cell activation and exhibits lower toxicity. CliMB-325 can be used for the study of colorectal cancer.
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- Formule: C15H9Cl2N9
- Masse moléculaire:386.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HSP90 |
MHC I 498 nM (EC50) |
CliMB-325 induces MHC-I (EC50 = 498 nM) expression on the surface of CT26 murine colorectal cancer cells[1].
CliMB-325 exhibits low cytotoxicity against CT26 murine colorectal cancer cells with a CC50 of 1.3 μM[1].
CliMB-325 (1 μM, 48 h) increases T cell activation (measured by β-galactosidase activity) by 1.6-fold when MC38-OVA cells, after a 48-hour incubation, are co-cultured with B3Z T cells[1].
CliMB-325 adds 290 unique MHC-I peptides, five times more than the untreated group, and 81.3% of the peptides are unique to the CliMB-325 group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 386.20
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Formule C15H9Cl2N9
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SMILES
ClC1=C2N=CN(C2=NC(N)=N1)CC3=CN(N=N3)C4=CC=C(C=C4C#N)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CliMB-325 Related Classifications
HY-179211 Related Classifications
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