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Cat. No.: HY-120367

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DTP348

DTP348 is an inhibitor for carbonic anhydrase IX with a K_i of 8.3 nM in vitro and an IC₅₀ of 19.26 μM in Xenopus oocytes. DTP348 exhibits slight toxicity in zebrafish embryos with LD₅₀ of 3.5 mM. DTP348 can be used in the anti-cancer research.

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CAS No.: 1383370-92-0
Formule: C₆H₁₁N₅O₄S
Masse moléculaire:249.25

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DTP348 Chemical Structure

CAS No.: 1383370-92-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
- Essai clinique
Chemical Information
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Description

IC₅₀ & Target

CA IX

8.3 nM (Ki)

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Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1383370-92-0
Masse moléculaire 249.25
Formule C₆H₁₁N₅O₄S
SMILES

O=S(NCCN1C([N+]([O-])=O)=CN=C1C)(N)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Aspatwar A, et al., Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1064-1073. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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DTP348

Voir tous les produits spécifiques à Isoform Carbonic Anhydrase

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IC50 & Target

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Pureté et documentation

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