EphB1-IN-2
EphB1-IN-2 is a mutant-selective kinase inhibitor of ABL and FGFR4, with an IC50 of 14 nM against ABLG321C mutant and 163 nM against FGFR4G556C mutant. EphB1-IN-2 shows selectively over wild-type ABL and FGFR4.
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- CAS No.: 2097512-73-5
- Formule: C17H15ClN4O2
- Masse moléculaire:342.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
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FGFR4 >10000 nM (IC50) |
EphB1-IN-2 (compound 10) shows 37-fold selective inhibition of ABLG321C over wild-type ABL, with IC50 values of 14 nM and 530 nM, respectively[2].
EphB1-IN-2 shows greater than 61-fold selective inhibition of FGFR4G556C over wild-type FGFR4, with an IC50 of 163 nM against FGFR4G556C and an IC50 greater than 10,000 nM against wild-type FGFR4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2097512-73-5
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Masse moléculaire 342.78
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Formule C17H15ClN4O2
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SMILES
O=C(CCl)NC1=CC2=NC=NC(NC3=CC(OC)=CC=C3)=C2C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EphB1-IN-2 Related Classifications
HY-183909 Related Classifications
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