Epsilon-V1-2
Based on 6 publication(s) in Google Scholar
Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC.
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- Pureté : 95.21%
- CAS No.: 182683-50-7
- Formule: C37H65N9O13
- Masse moléculaire:843.96
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Epsilon-V1-2
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Activité biologique
Description
IC50 & Target
[1]|
PKCε |
In Vitro
Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide containing the site for its specific receptor for activated C kinase (RACK), inhibits translocation of PKCε and reduces insulin response to glucose[1].
Epsilon-V1-2 (ε-V1-2; 1 μM, 24 hours) treatment significantly inhibits Oleic acid (OA)-induced connexin 43 (Cx43) Ser368 phosphorylation and prevents OA-induced gap junction disassembly in cardiomyocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice transplanted the hearts of FVB mice[3]
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Dosage:20 mg/kg/day
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Administration:0.1 mL osmotic pumps implanted subcutaneously; daily; for 4 weeks
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Result:Significantly improved the beating score throughout the treatment.
Chemical Information
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CAS No. 182683-50-7
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Appearance Solid
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Masse moléculaire 843.96
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Formule C37H65N9O13
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Color White to off-white
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Synonyms
ε-V1-2; EAVSLKPT
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Sequence Shortening
EAVSLKPT
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Sci Bull
2023 Jul 15;68(13):1413-1429. PMID: 37336688 -
Cell Death Dis
Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance. [Abstract]2022 Mar 28;13(3):275. PMID: 35347118 -
Antioxidants (Basel)
γ-Glutamylcysteine Exerts Neuroprotection Effects against Cerebral Ischemia/Reperfusion Injury through Inhibiting Lipid Peroxidation and Ferroptosis. [Abstract]2022 Aug 25;11(9):1653. PMID: 36139727 -
J Ovarian Res
Long non-coding ribonucleic acid SNHG18 induced human granulosa cell apoptosis via disruption of glycolysis in ovarian aging. [Abstract]2024 Sep 13;17(1):185. PMID: 39272131 -
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bioRxiv
Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution. [Abstract]2025 Jan 6:2025.01.06.631444. PMID: 39829776
Solvant et solubilité
In Vitro:
H2O : ≥ 100 mg/mL (118.49 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. M Yedovitzky, et al. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. J Biol Chem. 1997 Jan 17;272(3):1417-20. [Content Brief]
[2]. Yuahn-Sieh Huang, et al. Mechanism of oleic acid-induced gap junctional disassembly in rat cardiomyocytes. J Mol Cell Cardiol. 2004 Sep;37(3):755-66. [Content Brief]
[3]. Tomoyoshi Koyanagi, et al. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol. 2007 Oct;43(4):517-22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.1849 mL | 5.9245 mL | 11.8489 mL | 29.6223 mL |
| 5 mM | 0.2370 mL | 1.1849 mL | 2.3698 mL | 5.9245 mL | |
| 10 mM | 0.1185 mL | 0.5924 mL | 1.1849 mL | 2.9622 mL | |
| 15 mM | 0.0790 mL | 0.3950 mL | 0.7899 mL | 1.9748 mL | |
| 20 mM | 0.0592 mL | 0.2962 mL | 0.5924 mL | 1.4811 mL | |
| 25 mM | 0.0474 mL | 0.2370 mL | 0.4740 mL | 1.1849 mL | |
| 30 mM | 0.0395 mL | 0.1975 mL | 0.3950 mL | 0.9874 mL | |
| 40 mM | 0.0296 mL | 0.1481 mL | 0.2962 mL | 0.7406 mL | |
| 50 mM | 0.0237 mL | 0.1185 mL | 0.2370 mL | 0.5924 mL | |
| 60 mM | 0.0197 mL | 0.0987 mL | 0.1975 mL | 0.4937 mL | |
| 80 mM | 0.0148 mL | 0.0741 mL | 0.1481 mL | 0.3703 mL | |
| 100 mM | 0.0118 mL | 0.0592 mL | 0.1185 mL | 0.2962 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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