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Etevritamab

(Synonyms: AMG-596)
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Etevritamab (AMG-596) is a bispecific T-cell engager that targets EGFRvIII and CD3. Etevritamab simultaneously binds CD3 on T cells and EGFRvIII on glioblastoma multiforme cells, thereby forming a bridge structure. Etevritamab triggers T-cell activation, proliferation, secretion of cytotoxic substances, and tumor cell lysis. Etevritamab extends overall survival and induces tumor regression in mouse models of glioblastoma multiforme. Etevritamab can be used for research related to glioblastoma.

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  • Pureté: 97.00%
  • CAS No.: 2329692-74-0
  • Masse moléculaire:54.66 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Etevritamab
  • Experimental Validation Results for Etevritamab
  • Etevritamab Chemical Structure
    Etevritamab Chemical Structure
CAS No.: 2329692-74-0
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Etevritamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    (scFv-heavy-kappa)-(scFv-heavy-lambda)

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Etevritamab (HY-P99948). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Etevritamab Chemical Structure
    1/16
  • Etevritamab
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Etevritamab (HY-P99948). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)