FR191413
FR191413 is a selective bradykinin B2 receptor agonist that stimulates prostaglandin E2 production in WI-38 cells and activates BK B2 receptor-mediated pathways such as vasodilation and organ protection. FR191413 competitively binds to [3H]-BK in guinea pig ileum (GPI) membranes and CHO cells transfected with the human BK B2 receptor, with IC50 values of 20.0 nM and 2.60 nM, respectively. FR191413 can be used in research related to cardiovascular diseases and diabetes, including hypertension, myocardial hypertrophy, myocardial infarction, arrhythmias, and diabetic nephropathy.
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- CAS No.: 194928-55-7
- Formule: C34H31Cl2N7O5
- Masse moléculaire:688.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Bradykinin B2 Receptor (B2R) |
EP2 |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
0.68 nM
Compound: 47c
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Inhibition of [3H]BK (1.0 nM) binding to the human bradykinin receptor B2, expressed in CHO cells
Inhibition of [3H]BK (1.0 nM) binding to the human bradykinin receptor B2, expressed in CHO cells
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[PMID: 15139763] |
FR191413 binds to GPI membranes and human B2 receptor-expressing CHO cells with IC50 values of 20.0 nM and 2.60 nM, respectively, and stimulates prostaglandin E2 production in WI-38 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 194928-55-7
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Masse moléculaire 688.57
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Formule C34H31Cl2N7O5
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SMILES
O(CC1=C(Cl)C(N(C(CNC(/C=C/C=2C=CC(NC(C)=O)=NC2)=O)=O)C)=CC=C1Cl)C3=C4C(N(CC5=CC=CC=N5)C(OC)=N4)=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FR191413 Related Classifications
HY-118945 Related Classifications
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- FR191413
- 194928-55-7
- FR 191413
- FR-191413
- Prostaglandin Receptor
- Bradykinin Receptor
- GPI membranes
- human B? receptor-expressing CHO cells
- myocardial hypertrophy
- arrhythmias
- cardiovascular disease
- myocardial infarction
- bradykinin B2 receptor
- bradykinin B2 receptor agonist
- diabetic nephropathy
- WI-38 cells
- hypertension
- prostaglandin E?
- human models
- Inhibitor
- inhibitor
- inhibit