country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-133806

Copy Link Print Information

Fumarranol

Fumarranol, a Fumagillin (HY-B0751) analogue, is a selective type 2 methionine aminopeptidase (MetAP2) inhibitor with a human IC₅₀ of 3.2 μM. Fumarranol inhibits proliferation of bovine aortic endothelial cells and inhibits angiogenesis in a mouse matrigel plug model. Fumarranol can be used for the researches of cancer, diabetic retinopathy, age-related macular degeneration.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 912569-37-0
Formule: C₁₆H₂₄O₄
Masse moléculaire:280.36

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fumarranol Chemical Structure

CAS No.: 912569-37-0

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

MetAp2

3.2 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform MetAP :

Voir tous les produits spécifiques à Isoform VEGFR :

In Vitro

Fumarranol (0-100 μM) selectively inhibits recombinant hMetAP2 enzymatic activity with an IC₅₀ of 3.2 μM, and does not inhibit hMetAP1 at 100 μM^[1].
Fumarranol inhibits bovine aortic endothelial cell proliferation with an IC₅₀ of 34 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fumarranol (90 mg/kg) blocks the growth of new blood vessels in mice with , matrigel containing VEGF and basic FGF^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 912569-37-0
Masse moléculaire 280.36
Formule C₁₆H₂₄O₄
SMILES

O(C)[C@]12[C@](CO)([C@]1([C@]3(C)[C@@H](CC=C(C)C)O3)[H])CCC2=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lu J, et al. Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo. J Med Chem. 2006 Sep 21;49(19):5645-8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Fumarranol

Voir tous les produits spécifiques à Isoform MetAP

Voir tous les produits spécifiques à Isoform VEGFR