Cblb - Casitas B-lineage lymphoma b Gene

Also Known as Cbl-b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 208650

Summary

Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein Ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway. Acts upstream of or within several processes, including T cell receptor signaling pathway; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in membrane raft and plasma membrane. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Apr 2022]

Cblb Products (1)

mRNA Protein Name
NM_001033238.1 NP_001028410.1 E3 ubiquitin-protein ligase CBL-B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
12697763 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within T cell activation IMP
IMP: Inferred from mutant phenotype
11070165 MGI
acts upstream of T cell anergy IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12697763 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
11070165 MGI
acts upstream of or within intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
11070165 MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14738763 MGI
acts upstream of or within peptidyl-amino acid modification IDA
IDA: Inferred from direct assay
12697763 MGI
acts upstream of or within positive regulation of T cell anergy IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
12697763 MGI
acts upstream of protein catabolic process IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
12697763 MGI
acts upstream of or within regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
12697763 MGI
involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway IMP
IMP: Inferred from mutant phenotype
29237719 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
32606037 MGI
acts upstream of or within regulation of protein binding IMP
IMP: Inferred from mutant phenotype
12697763 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
32606037 MGI
Cellular Component GO Annotation Evidence Références Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
32606037 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
32606037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CBL-B

  • RING-type E3 ubiquitin transferase CBL-B

  • SH3-binding protein CBL-B

  • casitas B-lineage lymphoma proto-oncogene b

  • signal transduction protein CBL-B

Cblb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Cblb Q3TTA7 Cd5 Mus musculus P13379
Affinity Chrom
27474268
Intra
Cblb Q3TTA7 Cd5 Mus musculus P13379
Anti Bait CoIP
27474268
Intra
Cblb Q3TTA7 Ticam1 Mus musculus Q80UF7
Anti Tag CoIP
20639876
Intra
Cblb Q3TTA7 Ticam1 Mus musculus Q80UF7
Anti Bait CoIP
20639876
Intra
Cblb Q3TTA7 Myd88 Mus musculus P22366
Anti Bait CoIP
20639876
Intra
Cblb Q3TTA7 Myd88 Mus musculus P22366
Anti Tag CoIP
20639876
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-141432 NX-1607 Inhibitor 99.87% Phase 1

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-136339 Cbl-b-IN-1 Inhibitor 99.66% Unkown
HY-155815 MS9715 99.48% Unkown
HY-155120 Cbl-b-IN-5 Inhibitor 99.05% Unkown
HY-156766 Cbl-b-IN-10 Inhibitor 98.85% Unkown
HY-155477 Cbl-b-IN-15 Inhibitor 99.78% Unkown
HY-156765 Cbl-b-IN-9 Inhibitor 98.55% Unkown
HY-161977 Cbl-b-IN-26 Inhibitor 99.81% Unkown
HY-156769 Cbl-b-IN-13 Inhibitor 98.46% Unkown
HY-141431 Cbl-b-IN-2 Inhibitor / Unkown
HY-156768 Cbl-b-IN-12 Inhibitor / Unkown
HY-156762 Cbl-b-IN-6 Inhibitor / Unkown
HY-156763 Cbl-b-IN-7 Inhibitor / Unkown
HY-156764 Cbl-b-IN-8 Inhibitor / Unkown
HY-156767 Cbl-b-IN-11 Inhibitor / Unkown
HY-158171 Cbl-b-IN-17 Inhibitor / Unkown
HY-158173 Cbl-b-IN-19 Inhibitor / Unkown
HY-159608 PROTAC Cbl-b-IN-1 Degrader / Unkown
HY-163194 Cbl-b-IN-16 Inhibitor / Unkown
HY-164133 SM00465 Inhibitor / Unkown
HY-169005 Cbl-b-IN-27 Inhibitor / Unkown
HY-173311 Cbl-b-IN-28 / Unkown
HY-179575 Cbl-b-IN-29 / Unkown
HY-179617 Cbl-b-IN-30 Inhibitor / Unkown
HY-183293 Cbl-b-IN-32 Inhibitor / Unkown
HY-183997 Cbl-b-IN-33 / Unkown
HY-184236 Cbl-b-IN-34 Inhibitor / Unkown
HY-P11479 Cbl-b-IN-31 Inhibitor / Unkown
HY-P11481 FITC-Acp-RpYTPEP-NH2 Ligand / Unkown
HY-RS01997 CBLB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08508 MMAB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-141432G NX-1607 (GMP) Inhibitor / Unkown
HY-RS17948 Cblb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24419 Cblb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cblb NCBI NCBI:868