Indole
Based on 3 publication(s) in Google Scholar
Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule.
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- Pureté: 99.99%
- CAS No.: 120-72-9
- Formule: C8H7N
- Masse moléculaire:117.15
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Indole
MoreVoir tous les produits spécifiques à Isoform Endogenous Metabolite
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Activité biologique
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Microbial Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 2
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
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[PMID: 22386528] |
| HEp-2 | IC50 |
>50 μM
Compound: 24
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Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay
Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay
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[PMID: 27116711] |
| HL-60 | IC50 |
>50 μM
Compound: 24
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
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[PMID: 27116711] |
| MDA-MB-231 | IC50 |
>100 μM
Compound: 2
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Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
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[PMID: 22386528] |
| MRC5 | IC50 |
15.58 μM
Compound: 2
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Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay
Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay
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[PMID: 22386528] |
| NCI-H292 | IC50 |
>50 μM
Compound: 24
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Cytotoxicity against human NCI-H292 cells after 72 hrs by MTT assay
Cytotoxicity against human NCI-H292 cells after 72 hrs by MTT assay
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[PMID: 27116711] |
| SK-N-SH | IC50 |
1.78 μM
Compound: 2
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Cytotoxicity against human SK-N-SH cells after 48 hrs by MTT assay
Cytotoxicity against human SK-N-SH cells after 48 hrs by MTT assay
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[PMID: 22386528] |
| U-251 | EC50 |
>625 μM
Compound: Indole
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Antiproliferative activity against human U251MG cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human U251MG cells after 72 hrs by sulforhodamine B assay
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[PMID: 30568753] |
| U-87MG ATCC | EC50 |
>625 μM
Compound: Indole
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Antiproliferative activity against human U87MG cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human U87MG cells after 72 hrs by sulforhodamine B assay
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[PMID: 30568753] |
Indole (2 μM, 48 h) inhibits cell proliferation and cell connection damage in HCT116 and SW620 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116, SW620
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Concentration:2 μM
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Incubation Time:48 h
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Result:Inhibited cell growth and moderated cell cycle progression from G1 to S phase in CRC cell lines HCT116 and SW620.
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Cell Line:HCT116, SW620
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Concentration:2 μM
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Incubation Time:48 h
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Result:Increased protein expressions of occludin and claudin-3.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 120-72-9
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Appearance Solid
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Masse moléculaire 117.15
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Formule C8H7N
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Color Off-white to pale purple
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SMILES
C1(C=CC=C2)=C2NC=C1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Imeta
Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway. [Abstract]2024 Jan 15;3(1):e165. PMID: 38868519 -
Cell Metab
Gut microbial metabolism via hippocampal indole-AhR signaling regulates emotional symptoms. [Abstract]2026 Apr 1:S1550-4131(26)00097-5. PMID: 41928504 -
Solvant et solubilité
DMSO : 100 mg/mL (853.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 3.57 mg/mL (30.47 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.75 mg/mL (23.47 mM); Clear solution
This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.75 mg/mL (23.47 mM); Clear solution
This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (280 KB)
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SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Lee JH, et al. Indole as an intercellular signal in microbial communities. FEMS Microbiol Rev. 2010 Jul;34(4):426-44. [Content Brief]
[2]. Wang L, et al. Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway. Imeta. 2024 Jan 15;3(1):e165. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 8.5361 mL | 42.6803 mL | 85.3606 mL | 213.4016 mL |
| 5 mM | 1.7072 mL | 8.5361 mL | 17.0721 mL | 42.6803 mL | |
| 10 mM | 0.8536 mL | 4.2680 mL | 8.5361 mL | 21.3402 mL | |
| 15 mM | 0.5691 mL | 2.8454 mL | 5.6907 mL | 14.2268 mL | |
| 20 mM | 0.4268 mL | 2.1340 mL | 4.2680 mL | 10.6701 mL | |
| 25 mM | 0.3414 mL | 1.7072 mL | 3.4144 mL | 8.5361 mL | |
| 30 mM | 0.2845 mL | 1.4227 mL | 2.8454 mL | 7.1134 mL | |
| DMSO | 40 mM | 0.2134 mL | 1.0670 mL | 2.1340 mL | 5.3350 mL |
| 50 mM | 0.1707 mL | 0.8536 mL | 1.7072 mL | 4.2680 mL | |
| 60 mM | 0.1423 mL | 0.7113 mL | 1.4227 mL | 3.5567 mL | |
| 80 mM | 0.1067 mL | 0.5335 mL | 1.0670 mL | 2.6675 mL | |
| 100 mM | 0.0854 mL | 0.4268 mL | 0.8536 mL | 2.1340 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Indole Related Classifications
HY-W001132 Related Classifications
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