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Cat. No.: HY-182427

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ORF 17583

ORF 17583 is a Ranitidine (HY-B0693) analogue and H2 receptor antagonist. ORF 17583 exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing. ORF 17583 can be used for research on peptic ulcers and hyperacidity.

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CAS No.: 78441-46-0
Formule: C₁₃H₂₁N₅O₂S₂
Masse moléculaire:343.47

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Please store the product under the recommended conditions in the Certificate of Analysis.

ORF 17583 Chemical Structure

CAS No.: 78441-46-0

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Description

Voir tous les produits spécifiques à Isoform Histamine Receptor :

In Vitro

ORF 17583 (100-1000 nM; 30 min) exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing^[1].
ORF 17583 (1-10 μM; 60 min) significantly inhibits histamine-induced gastric acid secretion at a concentration of 10 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 78441-46-0
Masse moléculaire 343.47
Formule C₁₃H₂₁N₅O₂S₂
SMILES

O=S1N=C(C(NCCSCC2=CC=C(CN(C)C)O2)=N1)NC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Di Stilo A, et al. SAR studies on H2 antagonists containing alkylamino substituted 1,2, 5-thiadiazole 1-oxide moieties. Farmaco. 1998;53(8-9):536-540. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ORF 17583

Voir tous les produits spécifiques à Isoform Histamine Receptor

Activité biologique

Chemical Information

Pureté et documentation

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Calculators

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ORF 17583 Related Classifications

HY-182427 Related Classifications